7th International Conference on cGMP

cGMP: Generators, Effectors and
Therapeutic Implications

Program

Friday, June 19, 2015

13:00 Welcome Reception
Robert Schuman Haus
14:00 Harald Schmidt,
Maastricht		 Welcome to Trier
Session 1
Therapeutic
Breakthroughs		 Chair:
Harald Lapp, Erfurt
Johannes-Peter Stasch, Wuppertal
14:10 Martin Lefkowitz,
East Hanover		 LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure
14:35 Frank Misselwitz,
Wuppertal		 The clinical development of sGC modulators, riociguat and vericiguat
15:00 John Burnett,
Rochester		 MANP: A novel pGC A Receptor/cGMP activator for resistant hypertension: preliminary first in human clinical trial results
15:25 Steven Pullen,
Ridgefield		 A sGC activator protects from diabetic nephropathy beyond standard of care in the ZSF1 rat
15:50 Jaime Masferrer,
Boston		 The discovery and characterization of novel sGC stimulators
16:15–16:45 COFFEE BREAK
Session 2
cGMP and
Metabolism		 Chair:
John Burnett, Rochester
Kazuma Nakao, Kyoto
16:45 Alexander Pfeifer,
Bonn		 Stimulation of sGC protects against obesity by recruiting brown adipose tissue
17:10 Sheila Collins,
Orlando		 Natriuretic peptides and cGMP in metabolic disease
17:35 Justin Percival,
Miami		 Soluble guanylyl cyclase regulates skeletal muscle fiber type plasticity, fatigue resistance and whole body insulin resistance
18:00-20:00
Session 3
Poster Visit		 SNACK AND REFESHMENTS
WINE AND BEER
Evening Lecture Chair:
Michael Mendelsohn, Boston
20:00–21:00 Martin Biel,
München		 Gene therapy approaches to restore retinal cGMP channel function

Saturday, June 20, 2015

Session 4
FOR 2060:
cGMP in Cell
Growth & Survival		 Chair:
Franz Hofmann, München
Doris Koesling, Bochum
08:30 Renate Pilz,
San Diego		 NO/GMP as mediators of estrogen effects in bone
08:55 Darren Browning,
Augusta		 Using PDE5 inhibitors for the prevention and treatment of colorectal cancer
09:20 Viacheslav Nikolaev,
Hamburg		 cGMP and cardiac hypertrophy
09:45 Robert Feil,
Tübingen		 cGMP signalling and melanoma
10:10 Robert Lukowski,
Tübingen		 Cyclic GMP/cGMP-dependent protein kinase type I signaling and cysteine-rich LIM-only protein 4 in AngII/AT1R-induced heart hypertrophy and fibrosis
10:35-11:00 COFFEE BREAK
Session 5
sGC/GK Structure
and Assays		 Chair:
Roland Seifert, Hannover
Günter Schultz, Berlin
11:00 Hirokazu Arimoto,
Sendai		 Roles of 8-nitro-cGMP in autophagy regulation
11:25 Choel Kim,
Houston		 Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II
11:50 Albert Smolenski,
Dublin		 cGMP and cAMP pathways rearrange ARHGAP17 and ARHGEF6 protein complexes to control Rac1 in platelets
Session 6
PDEs		 Chair:
Harald Schmidt, Maastricht
Adrian Hobbs, London
12:15 David Kass,
Baltimore		 New insights into leveraging PKG signalling to treat diseased hearts
12:40 Jos Prickaerts,
Houston		 Targeting cyclic nucleotides in CNS drug discovery: a translational approach into cognition enhancement
13:05 Holger Rosenbrock,
Biberach 		Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement
13:10-14:30
Session 7
Poster Visit		 SNACK AND REFESHMENTS
15:00-17:00 TRIER VISIT
Guided city walk through historic Trier,
Chamber concert - Kurfürstliche Palais
17:00-18:00 CHAMBER CONCERT
Kurfürstliche Palais Trier
18:00-20:00 SNACK AND REFESHMENTS
Ferid Murad
Lecture		 Chair:
Ferid Murad,
Washington
20:00–21:00 Benjamin Kaupp,
Bonn		 Ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

Sunday, June 21, 2015

Session 8
GC and
Heart/Kidney		 Chair:
Michaela Kuhn, Würzburg
Andreas Papapetropoulos, Athens
08:30 Thomas Krieg,
Cambridge		 Mechanism and protective properties of S-nitrosation by nitric oxide in cardiac mitochondria
08:55 Frank Schweda,
Regensburg		 Novel roles of cardiac natriuretic peptides in renal compensatory hypertrophy
09:20 Jens Schlossmann,
Regensburg		 Antifibrotic function of cGKI in the kidney
09:45 Robert Blanton,
Boston 		Mixed linage kinase 3 functions as a cGMP-dependent protein kinase I alpha substrate and regulates blood pressure and cardiac remodeling in vivo
10:10-10:40 COFFEE BREAK
Session 9
GC and
Vasculature		 Chair:
Jens Schlossmann, Regensburg
Robert Feil, Tübingen
10:40 Paul Vanhoutte,
Hong Kong		 The cyclic nucleotide 3’,5’-cIMP produced by sGC is a second messenger in the vascular wall
11:05 Dennis Stuehr,
Cleveland 		sGC redox regulation and asthma
11:30 Adrian Hobbs,
London		 Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP)
11:55 Kazuwa Nakao,
Kyoto		 Implication of C-type natriuretic peptide derived from vascular endothelial cells on blood pressure regulation
12:20-14:00
Session 10
Poster Visit		 SNACK AND REFESHMENTS
Session 11
Session 11
Other Functions
of GCs II		 Chair:
Scott Waldman, Philadelphia
Andreas Friebe, Würzburg
14:00 Ruey-Bing Yang,
Taipei		 Receptor guanylyl cyclase-G is a sensory protein activated by cool temperatures and predator odor 2,4,5-trimethylthiazoline
14:25 Laurinda Jaffe &
Lincoln Potter
Minneapolis		 Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption
14:50 Scott Waldman,
Philadelphia		 Hormone suppression silencing GUCY2C is required for colorectal cancer
15:15 Peter Brouckaert,
Ghent		 Phenotyping apo-sGC mice and lessons for the development of sGC activators
Session 12
Poster Presentation		 Chair:
Adrian Hobbs, London
Annie Beuve, Newark
15:40–16:30 6 selected posters Each candidate may talk for 5 min and show up to 5 slides or overheads and allow for 2 min question time

5 minute rapid fire oral presentations of selected posters
Session 13
Committee
Meetings		  
16:30 – 17:00 Poster Prize Committee Selected out of poster presentations
17:00 – 18:30 Nomenclature Committee  
19:00 AWARD DINNER – VINEYARD DEUTSCHHERRENHOF
AWARD CEREMONY
FAREWELL PARTY
Postersessions
  1. Luis Agulló, Ignasi Buch, Hugo Gutiérrez de Terán, Gianni de Fabritis, David Garcia Dorado, Jordi Villà-Freixa
    Computational exploration of the binding mode of the heme-dependent activator YC-1 into the active catalytic site of soluble guanylate cyclase

  2. Robert M H Allen, Aniruthan Renukanthan, Kristen J Bubb, Inmaculada C Villar, Amie J Moyes, Reshma S Baliga, Adrian J Hobbs
    Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis

  3. Gaia Calamera, Andrea Hembre Ulsund, Ornella Manfra, Jeong Joo Kim, Choel Kim, Finn Olav Levy, Kjetil Wessel Andressen
    Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum

  4. Elisabeth Angermeier, Katrin Domes, Franz Hofmann
    Anemia of cGKI deficient mice is caused by intestinal bleeding

  5. Katharina Beck, Dieter Groneberg, Andreas Friebe, Barbara Lies
    A case of chaos? NO causes arrhythmic motor pattern via interstitial cells of Cajal in the murine colon

  6. Naveen L Pereira, Nirubol Tosakulwong, Christopher G Scott, Gregory D Jenkins, Naresh Prodduturi, Yubo Chai, Timothy M Olson, Richard J Rodeheffer, Margaret M Redfield, Richard M Weinshilboum, John C Burnett, Jr.
    Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated with Reduced NT-proANP, Increased Stroke and Higher Diastolic Blood Pressure

  7. Wolfgang S Lieb, Stefan Munster, Ana C Dordea, Sara Vandenwijngaert, Robert E Tainsh, Peter Brouckaert, Warren M Zapol, Emmanuel S Buys
    Inhaled Nitric Oxide: an sGC-dependent IOP lowering agent

  8. Ana I Casas, Friederike Langhauser, Vu Thao-Vi Dao, Emre Guney, Pamela WM Kleikers, Manuela García López, Jörg Menche, Albert-László Barabási, Christoph Kleinschnitz, Harald HHW Schmidt
    A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival

  9. Ying-Chi Chao, Ruey-Bing Yang
    The predator odor 2,4,5-trimethylthiazoline binds and activates receptor guanylyl cyclase-G to elicit innate defensive responses

  10. Wen Chen, Katharina Völker, Birgit Gaßner, Franziska Werner, Anja Rabenhorst, Karin Hartmann, Michaela Kuhn
    C-type natriuretic peptide prevents activation of perivascular mast cells and inflammation in the postischemic microvasculature

  11. Miriam M Cortese-Krott, Gunter GC Kuhnle, Alex Dyson, Bernadette O Fernandez, Marian Grman, Mark P Barrow, George McLeod, Karol Ondrias, Péter Nagy, Mervyn Singer, Malte Kelm, Anthony R Butler, Martin Feelisch
    Nitrosopersulfide (SSNO-) targets soluble guanylyl cyclase and induces vasodilation in vivo

  12. Tan A Dang, Jana Wobst, Thorsten Kessler, Simon v. Ameln, Manuel Lehm, Matthias Prestel, Ingrid Braenne, Redouane Aherrahrou, Martin Dichgans, Christian Hengstenberg, Jeanette Erdmannn, Heribert Schunkert
    Investigating the impact of a mutation in PDE5A on myocardial infarction

  13. Deborah M Dickey, Aaron B Edmond, Thomas Chaffee, Lincoln R Potter
    Catalytically Active Guanylyl Cyclase-B Requires Glycosylation and Mutations That Inhibit This Process Cause Dwarfism

  14. Fanni Dittmar, Salim Seyfried, Volkhard Kaever, Roland Seifert
    Zebrafish as model organism for cNMP research

  15. Sarah Dünnes, Dieter Groneberg, Volker Herold, Peter Jakob, Andreas Friebe
    Arterial stiffness and collagen expression in mice lacking NO-sensitive guanylyl cyclase

  16. Aaron B Edmund, Lincoln R Potter
    Mutation of a conserved lysine in the kinase homology domain reduces the natriuretic peptide-dependent activity and phosphorylation of guanylyl cyclase-A

  17. Arne Fabritius, Oliver Griesbeck
    Design and Directed Evolution of Genetically Encoded cGMP Sensors

  18. Sandeep Dhayade, Susanne Feil, Anja Ulmer, Susanne Kaesler, Tobias Sinnberg, Martin Thunemann, Ulrike Naumann, Tilo Biedermann, Birgit Schittek, Robert Feil
    A CNP-cGMP-cGKI-MAPK pathway promotes melanoma growth in vitro and in vivo in mice

  19. Sandra Frankenreiter, Angelina Kniess, Peter Ruth, Thomas Krieg, Andreas Friebe, Robert Lukowski
    Cyclic GMP signaling and mitochondrial BK channels in cardioprotection against ischemia/reperfusion injury

  20. Eugen Franz, Jeong Joo Kim, Olga Schneider, Daniela Bertinetti, Choel Kim, Friedrich W Herberg
    The Role of a Parasite-Specific D-Site in Activation of Plasmodium falciparum cGMP-Dependent Protein Kinase

  21. Andreas Friebe, Sarah Dünnes, Viacheslav Nikolaev, Barbara Lies, Dieter Groneberg
    Modulation of cGMP/cAMP crosstalk on the level of PDE3 in animals lacking NO-sensitive guanylyl cyclase

  22. Stepan Gambaryan, Igor Mindukshev, Natalia Rukoyatkina, Iraida Sharina, Emil Martin, Ulrich Walter
    Erythrocytes do not produce biologically active NO

  23. Peter Germano, Jenny Tobin, Robert Jefferson, Courtney Shea, Adaline Smith, G-Yoon Jamie Im, James Sheppeck II,James Wakefield, Kristie Sykes, Maria Ribadeneira, Samuel Rivers, Jaime Masferrer
    Concomitant administration of sGC stimulators with common classes of anti-hypertensive agents results in increased efficacy in spontaneously hypertensive rats

  24. Jan Giesen, Ernst-Martin Füchtbauer, Doris Koesling, Michael Russwurm
    NO-dependent cGMP signalling in neurons and astrocytes

  25. Dieter Groneberg, Annemarie Aue, Barbara Lies, Andreas Friebe
    Cell-specific modulation of gastrointestinal NO-induced relaxation by phosphodiesterases

  26. N Haase, N Wilck, L Marko, A Balogh, A Heuser, D Brockschnieder, A Kretschmer, JP Stasch, DN Müller, R Dechend
    The sGC stimulator BAY 41-8543 in a rat model of hypertension-induced heart failure

  27. Michael Huntgeburth, Johannes Kießling, Gerrit Weimann, Verena Kiepsel, Soundos Saleh, Nicolas Hunzelmann, Stephan Rosenkranz
    The sGC-stimulator Riociguat for the treatment of Raynaud’s phenomenon: A single-dose, double-blind, randomized, placebo-controlled cross-over study (DIGIT)

  28. Takashi Nakai, Nicholas R Perl, Rajesh R Iyengar, Ara Mermerian, G-Yoon J Im, Thomas W-H Lee, Glen R Rennie, James Jia, Paul A Renhowe, Timothy C Barden, James E Sheppeck II, Karthik Iyer, Joon Jung, G. Todd Milne, Chrissie Segal, Kimberly Long, Joy Miyashiro, Sylvie Bernier, Sarah Jacobson, Jenny Tobin, Courtney Shea, Peter Germano, Yueh-tyng Chien, Daniel Zimmer
    Discovery of IWP-051, a Novel Orally Bioavailable Soluble Guanylate Cyclase Stimulators with Sustained and Dose-Dependent Hemodynamic Effects

  29. Nicole M Jackson, Brian P Ceresa
    Cyclic GMP Dependent Protein Kinase (PKG) as a mediator of EGFR-Induced Apoptosis in Breast Cancer

  30. Toru Kimura, Takashi Nojiri, Hiroshi Hosoda, Mikiya Miyazato, Kenji Kangawa
    CNP/GC-B signaling attenuates nephrotoxicity induced by cisplatin

  31. Ralf Erkens, Christian M Kramer, Christina Panknin, Lisann Krause, Mathias Weidenbach, Thomas Krenz, Evanthia Mergia, Malte Kelm, Miriam M Cortese-Krott
    The NO-cGMP pathway participates in vascular adaptation to oxidative stress in Nrf2 KO mice

  32. Moritz Lehners, Hyazinth Dobrowinski, Michael Krämer, Daniel Stehle, Martin Thunemann, Robert Feil
    Correlation of vascular smooth muscle cell phenotype and cGMP signalling

  33. Robin Lorenz, Daniel He, Choel Kim, Chinten J Lim, Friedrich W Herberg
    Rational design of a PKA-based sensor for cGMP

  34. Alessandra Borgognone, Thomas Loka, Myriam Chimen, Ed Rainger, Martin Feelisch, Steve P Watson, Michael P Frenneaux, Melanie Madhani
    Nitrite is a cGMP generator in isolated platelets

  35. Silja Meier, Lise Román Moltzau, Kjetil Wessel Andressen, Jan Magnus Aronsen, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Eirik Qvigstad, Finn Olav Levy
    CNP through NPR-B potentiates β1-andrenoceptor signaling in normal and failing hearts

  36. Evanthia Mergia, Stefanie Köhler-Bachmann, Michelle Puschkarow, Doris Koesling
    Contribution of the NO-GC isoforms to airway responsiveness

  37. Markus Milde, Martin Thunemann, Hariharan Subramanian, Katrin Ganzenberg, José Aparicio, Gülce Gülcüler, Viacheslav O. Nikolaev, Robert Feil
    Comparative analysis of established and new biosensors for cyclic nucleotides

  38. Dorit Möhrle, Nicole Eichert, Steffen Wolter, Evanthia Mergia, Doris Koesling, Andreas Friebe, Marlies Knipper, Lukas Rüttiger
    Differential role of NO-sensitive guanylyl cyclase isoforms NO-GC1 and NO-GC2 in auditory function in adult mice

  39. Henriette Andresen, Lise Román Moltzau, Steffen Fagerheim, David Gloriam4 Trond Bach, Finn Olav Levy
    Identification and characterization of small molecular NPR-B receptor antagonists

  40. Hitoshi Nakagawa, Yasuki Nakada, Yoshihiko Saito
    Natriuretic peptides regulate sympathetic nervous activity independent of mineralocorticoid receptor

  41. Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Toru Kimura, Meinoshin Okumura, Kenji Kangawa
    Clinical Significance of Atrial Natriuretic Peptide in Cancer Recurrence following Cancer Surgery

  42. Aikaterini Argyriou, Marina Bantzi, Athanassios Giannis, Andreas Papapetropoulos, Georgios A Spyroulias
    NMR study of a soluble Guanylate Cyclase (sGC) human homologue: the H-NOX domain from Nostoc sp.

  43. Jonas Petersen, Evanthia Mergia, Oliver Drees, Ruirui Lu, Catherine Real, Andreas Friebe, Doris Koesling, Achim Schmidtko
    Functions of NO-GC1 and NO-GC2 in pain processing

  44. Oleksandra Prysyazhna, Joseph R Burgoyne, Philip Eaton
    Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation

  45. Bilal M Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Klaus Peter Hofmann, Christian MT Spahn, Martin Heck
    Asymmetric Properties of Rod cGMP Phosphodiesterase 6 (PDE6): Structural and Functional Analysis

  46. Yvonne Reinke, Stefan Gross, Lars G Eckerle, Isabel Hertrich, Mathias Busch, Raila Busch, Alexander Riad, Bernhard H Rauch , Johannes-Peter Stasch, Marcus Dörr, Stephan B Felix
    Riociguat and cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

  47. Konstanze Roloff, Franziska Werner, Marco Abeßer, Katharina Völker, Hideo A Baba, Kai Schuh, Michaela Kuhn
    C-type natriuretic peptide prevents angiotensin II-induced cardiac remodelling and dysfunction

  48. Stephan Rosenkranz, Hossein-Ardeschir Ghofrani, Maurice Beghetti, Dunbar Ivy, Arno Fritsch, Gerrit Weimann, Soundos Saleh, Christian Apitz, Reiner Frey
    Riociguat for pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD): A subgroup analysis from the PATENT studies

  49. Olena Rudyk, Oleksandra Prysyazhna, Lan Zhao, Philip Eaton
    Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension

  50. Lukas Rüttiger, Ksenia Varakina, Dorit Möhrle, Dan Bing, Peter Sandner, Marlies Knipper
    Age, noise and cGMP: Pharmacological activation of soluble guanylyl cyclase (sGC) interacts with the progression of age related and noise induced hearing loss

  51. Soundos Saleh, Reiner Frey, Corina Becker, Sigrun Unger, Georg Wensing, Wolfgang Mück
    Bioavailability, pharmacokinetics and safety of riociguat given as an oral suspension or crushed tablet with and without food

  52. Abhishek Sanyal, Linda Sarah Hoffmann, Jennifer Etzrodt, Alexander Pfeifer
    Effects of obesity on sGCβ1 mediated signaling in white adipose tissue

  53. Erich Schneider, Sabine Wolter, Fanni Dittmar, Gonzalo Fernández, Roland Seifert
    Differentiation between first- and second messenger effects of cGMP

  54. Roland Seifert, Christina Hartwig, Sabine Wolter, Erich Schneider, Heike Bähre, Volkhard Kaever
    cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems

  55. Courtney Shea, Sheila Ranganath, Guang Liu, Derek Wachtel, Peter Germano, Jenny Tobin, Ping Zhang, Samuel Rivers, G-Yoon Jamie Im, James Sheppeck II, Jaime Masferrer
    IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model

  56. Sindhuja Sridharan, R Manjunatha Kini
    Snake venom natriuretic peptides: Potential molecular probes

  57. Marina Dobrivojevic, Katarina Spiranec, Dunja Gorup, Igor Erjavec, Srecko Gajovic, Aleksandra Sindic
    The effect of natriuretic peptides and bradykinin on development of brain oedema after ischemic stroke

  58. Katarina Spiranec, Sabrina Hupp, Birgit Gaßner, Aleksandra Sindic, Michaela Kuhn
    Natriuretic peptides, via GC-A/cGMP, moderate hypoxia-induced VEGF release from astrocytes and thereby pathological neovascularization in the retina

  59. P Stamm, A Jabs, M Oelze, Y Mikhed, S Kröller-Schön, P Welschof, T Jansen, M Hausding, M Kopp, S Steven, E Schulz, J-P Stasch, T Münzel, A Daiber
    Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

  60. Hariharan Subramanian, Alexander Froese, Daniela Hübscher, Konrad R Götz, Viacheslav O Nikolaev
    Direct visualization of cGMP microdomains in adult cardiomyocytes

  61. Sabine Tauscher, Hitoshi Nakagawa, Katharina Völker, Birgit Gaßner, Saskia Pröhl, Michaela Kuhn
    Role of atrial natriuretic peptide (ANP) in the regulation of insulin secretion and vitality of pancreatic ß cells

  62. Masashi Tawa, Takeshi Kinoshita, Tohru Asai, Tomoaki Suzuki, Takeshi Imamura, Tomio Okamura
    Influence of Smoking on Vascular Reactivity to cGMP Generators in Human Internal Thoracic Arteries

  63. Boris Tchernychev, Gerhard Hannig, David Arthur, Pei Ge, Jenny Tobin, Inmaculada Silos-Santiago
    Linaclotide-induced electrolyte secretion in human and rat colon: Ussing chamber studies

  64. Jagamya Vijayraghavan, Focco van den Akker
    Identification of new inhibitors of soluble guanylyl cyclase activity

  65. Sara Vandenwijngaert, Melissa Swinnen, Hilde Gillijns, Ellen Caluwé, Robert E Tainsh, Daniel I Nathan, Kaitlin Allen, Jozef Bartunek, Peter Brouckaert, Marielle Scherrer-Crosbie, Kenneth D Bloch, Stefan P Janssens, Emmanuel S Buys
    Cardiac soluble guanylate cyclase protects against the cardiac dysfunction induced by chronic doxorubicin treatment in mice

  66. Sara Vandenwijngaert, Ana C Dordea, Victor Garcia, Robert E Tainsh, Daniel I Nathan, Michael J Raher, Kaitlin Allen, Fan Zhang, Wolfgang S Lieb, Sarah Mikelman, Andrew Kirby, Christine Stevens, Robrecht Thoonen, Allyson Hindle, Patrick Y Sips, Rajeev Malhotra, Mark J Daly, Peter Brouckaert, Kenneth D Bloch, Michal Schwartzman, Emmanuel S Buys
    Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE

  67. Lai Wen, Martin Thunemann, Kjestine Schmidt, Cor de Wit, Susanne Feil, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Robert Feil
    Real-time imaging of cGMP signals in platelets

  68. Veronika Wetzl, Lothar Faerber, Franz Hofmann, Elisabeth Schinner, Jens Schlossmann
    Role of cGMP dependent protein kinase I in renal antifibrotic signaling of serelaxin and zaprinast

  69. Jana Wobst, Tan An Dang, Thorsten Kessler, Simon von Ameln, Stephanie Tennstedt, Christian Hengstenberg, Jeanette Erdmann, Heribert Schunkert
    Functional evaluation of GUCY1A3 mutations associated with myocardial infarction risk

  70. Stefanie Wolfertstetter, Frank Schwede , Franz Hofmann, Jens Schlossmann
    Interaction of cCMP with the cGK, cAK and MAPK kinases in murine tissues

  71. Steffen Wolter, Dorit Möhrle, Dennis Zelle, Marlies Knipper, Hannes Schmidt, Lukas Rüttiger
    72. The role of particulate guanylyl cyclase B (GC-B) in auditory function in adult mice

home | scientific organizers | program | further information | abstracts | registration | events | sponsors | impressum | privacy<