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Friday, June 10, 2005
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| 14:00 |
Ferid Murad,
Houston |
Welcome and Opening
Remarks |
Session 1
Molecular Mechanism |
Chair: Ferid Murad, Houston
Harald Schmidt, Melbourne |
| 14:15 |
Michael Marletta, Berkeley
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Molecular steps in sGC activation
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| 14:40 |
John Garthwaite, London
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New vistas on NO-cGMP signaling |
| 15:05 |
Teizo Kitagawa, Okazaki |
Resonance raman investigation of effects of YC-1 and GTP on structure of CO-bound heme of soluble guanylate cyclase |
Session 2
CNS & Applications |
Chair: John Garthwaite, London
Franz Hofmann, München |
| 15:30 |
Vicente Felipo, Valencia |
Role of cGMP in learning: alternations in pathological situations and therapeutic implications |
15:55
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Martin Hendrix, Wuppertal |
Selective inhibitors of cGMP phosphodiesterases as procognitive agents |
16:20 - 16:50
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COFFEE BREAK |
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| 16:50 |
Urs Albrecht, Fribourg
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Role of cGMP dependent protein kinases in the circadian system |
17:15
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David Morton, Portland
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Atypical soluble guanylate cyclases in Drosophila as neuronal oxygen sensors and their involvement in gustation
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17:40
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David Raizen,
Philadelphia
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A cGMP-dependent protein kinase plays a pivotal role in the control of behavioral quiescence in C. elegans
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Poster Session |
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18:00 - 20:00
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SNACKS AND REFRESHMENTS
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Evening Lecture |
Chair: Günter Schultz, Berlin
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| 20:00 |
Joe Beavo, Seattle |
Regulation of cyclic nucleotide hydrolysis by cGMP
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Saturday, June 11, 2005
Session 3
Cell Biology
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Chair: Joe Beavo, Seattle
Michael Marletta, Berkeley |
| 9:00 |
Doris Koesling, Bochum |
NO/cGMP signaling |
| 9:25 |
Werner Müller-Esterl,
Frankfurt
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Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase |
| 9:50 |
Annie Beuve, Newark
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Does sGC need a chaperone?
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Session 4
cGMP Targets |
Chair: Ulrich Walter, Würzburg
Peter Brouckaert, Gent |
10:05
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Jens Schlossmann, München |
Function of IRAG for cGMP kinase signaling in smooth muscle and platelets
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10:30
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Thomas Lincoln, Alabama
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PKG regulation of smooth muscle gene expression |
10:45
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Wolfgang Dostmann, Burlington |
Exploring vasomotor mechanisms using PKG specific inhibitors |
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11:00 - 11:30
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COFFEE BREAK |
| 11:30 |
Renate Pilz,
La Jolla |
Regulation of PKG expression in vascular smooth muscle cells |
11:55
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Joachim Schultz, Tübingen
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Bacterial GAF-domaines
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Session 5
Pharmacology |
Chair: John Burnett, Rochester
Johannes-Peter Stasch, Wuppertal |
| 12:20 |
Christiane Rothkegel, Wuppertal |
Beyond NO and heme: biochemical and pharmacological opportunities
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12:45
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Ursula Schindler, Frankfurt
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Role of activators of ferric sGC in cardiovascular disease |
| 13:10 |
Barbara
Kemp-Harper,
Melbourne
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The nitroxyl anion (NO-): a novel regulator of sGC and vascular tone |
13:25
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Nina Grosser,
Halle
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Aspirin activates HO-1 expression in endothelial cells - role of NO/cGMP |
Poster Session
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| 13:40 - 14:30 |
SNACKS AND REFRESHMENTS
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| 15:00 - 18:00 |
SANSSOUCI GARDEN WALK
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| 19:00 - 22:00 |
HAVEL RIVER BOAT TRIP
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Sunday, June 12, 2005
Session 6
Cardio-vascular Applications |
Chair: Renate Pilz, La Jolla
Vicente Felipo, Valencia |
| 9:00 |
John Burnett, Rochester |
cGMP enhancing strategies for acute and chronic heart failure
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| 9:25 |
Michael Mendelsohn, Boston
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Control of vascular remodeling by cGMP kinase
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9:50
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Ulrich Walter, Würzburg
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Functional role of cGMP-dependent VASP phosphorylation in vascular cells |
| 10:15 |
David Tulis,
Durham |
NO-independent regulation of the vascular injury response |
| 10:30 |
David Kass, Baltimore |
Role of PDE5a in cardiac stress response |
10:55 - 11:25
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COFFEE BREAK
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11:25
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John Parker, Toronto |
Differential effects of nitric oxide donors and phosphodiesterase V inhibitors on vascular function in humans |
Session 7
Pulmonary Applications |
Chair: Christian Schudt, Konstanz
Warren Zapol, Boston |
| 11:50 |
Oleg Evgenov, Boston
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sGC stimulator reverses acute pulmonary hypertension and augments the response to inhaled NO in awake lambs |
| 12:15 |
Ardeschir Ghofrani, Giessen
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sGC activation in pulmonary hypertension
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12:40
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Steve Abman, Denver
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NO/cGMP signaling in the pathogenesis and treatment of persistent pulmonary hypertension in the newborn
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13:05 - 14:00
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LUNCH
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Session 8
Renal Applications |
Chair: Suzanne Lohmann, Würzburg
Adrian Hobbs, London |
| 14:00 |
Michaela Kuhn, Würzburg
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Endothelium-mediated actions of the ANP/cGMP system |
14:25
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Harm Peters,
Berlin
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ole of sGC in progressive renal fibrosis |
14:40
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Robert Carey, Charlottesville
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Role of cGMP in natriuresis and pressure-natriuresis
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15:05
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Keith Thornbury,
Dundalk
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Effects of stimulating the cGMP pathway on spontaneous activity in pacemaker cells isolated from the rabbit urethra |
15:20
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Wolf-Georg Forssmann, Hannover
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Urodilatin, the renal natriuretic peptide: preclinical and clinical review
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Session 9
Genetic Models |
Chair: Michaela Kuhn, Würzburg
Werner Müller-Esterl, Frankfurt |
15:35
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Peter Brouckaert, Gent
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Phenotypes of sGC deficient mice
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16:00 - 16:30
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COFFEE BREAK
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16:30
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Robert Feil, München |
Genetic dissection of signaling via cGMP-dependent protein kinases
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16:55
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Ferid Murad, Houston
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Role of NO and cGMP in proliferation and differentiation of murine and human embryonic stem cells
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17:20
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Peter Ruth, Tübingen
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Analysis of BKCa deficient mice
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18:45
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COCKTAILS AND DINNER Crown Estate of Bornstedt
FAREWELL PARTY
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Poster Session
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- Abbey, Sarah E., Dmitri Smirnov, Lincoln R. Potter
Differential regulation of NPR-B/GC-B by protein kinase C and calcium
- Antl, Melanie, Katja Sigl, Christina Eigelsperger, Matthias Werner, Franz Hofmann, Jens Schlossmann
IRAG is involved in NO/cGMP-mediated inhibition of platelet function
- Antos, Laura K., Sarah E. Abbey-Hosch, Darcy R. Flora, Lincoln R. Potter
ATP-independent activation of natriuretic peptide receptors
- Blume, Constanze, Kai Schuh, Peter Benz, Ulrich Walter, Thomas Renné
In vivo modulation of vasodilator stimulated phosphoprotein functions by phosphorylation
- Boerrigter, Guido, Lisa C. Costello-Boerrigter, Harald Lapp, Johannes-Peter Stasch, John C. Burnett,
Co-activation of soluble and particulate guanylate cyclase by BAY 58-2667 and BNP enhances cardiorenal function in experimental heart failure
- Bonartsev, Anton, Alexander Postnikov, Marina Artemieva, Natalia Medvedeva
3-(3-[1,2,4]triazolo)-oxatriazolium-5-olate causes vasodilatation by NO-independent activation of soluble guanylate cyclase
- Buys, Emmanuel, Fumito Ichinose, John G. Morgan, Marielle Scherrer-Crosbie, Kenneth D. Bloch
Myocyte-specific overexpression of NOS3 prevents endotoxin-induced myocardial dysfunction in mice
- Cawley, Sharon M. and Wolfgang R. Dostmann Kinetics of NO-induced Cyclic GMP responses in vascular smooth muscle
- Castro, Liliana, Grégoire Vandecasteele, Rodolphe Fischmeister
PDE2 and PDE5 exert specific and distinct roles in regulating cGMP signals elicited by particulate or soluble guanylyl cyclases in rat cardiac myocytes
- Craven, Michael, Keith Thornbury, Gerard Sergeant, Mark Hollywood, Noel McHale
Regulation of spontaneous activity in rabbit corpus cavernosum myocytes by nitric oxide.
- Day, Jonathan P., Miles D. Houslay, Shireen-A. Davies
A novel role for cGMP-specific phosphodiesterase, PDE6, in active transport of cGMP
- De Vente, Jan, Marjanne Markerink-van Ittersum, James I. Gillespie
NO-cGMP signaling in the guina pig bladder
- Deile, Martin, César Ibarra-Alvardo, Pavel I. Nedvetsky, Helmut Müller, Barbara Kemp-Harper, Johannes-Peter Stasch, H.H.H.W. Schmidt Effects of nitric oxide on sGC redox states
- Dhaese, Ingeborg, Gwen Vanneste, Patrick Sips, Emmanuel Buys, Peter Brouckaert, Romain Lefebvre
NO-induced motility effects in distal colon of sGC a 1 knockout mice
- Domek-Lopacinska, Katarzyna, Marjanne Markerink-van Ittersum, Harry Steinbusch, Jan de Vente
Changes in expression of cGMP selective phosphordiesterses 2, 5 and 9 in the rat brain during aging
- Dumitrascu, Rio, Norbert Weissmann, Hossein Ardeschir Ghofrani, Knut Beuerlein, Harald Schmidt, Johannes-Peter Stasch, Mark Jean Gnoth, Werner Seeger, Friedrich Grimminger, Ralph Theo Schermuly
Activation of soluble guanylate cyclase reverses pulmonary vascular remodeling induced by hypoxia in mice
- Feil, Susanne, Patricia Zimmermann, Anna-Maria Knorn, Sabine Brummer, Jens Schlossmann, Franz Hofmann, Robert Feil
Immunohistochemical analysis of cGKI expression in the murine brain and eye
- Friebe, Andreas, Evanthia Mergia, Oliver Dangel, Alexander Lange, Doris Koesling
Gene inactivation of the β 1 subunit of NO-sensitive guanylyl cyclase in mice
- Gambaryan, Stepan, Michaela Kuhn, Ulrich Walter
Inhibition of agonist-stimulated aldosterone production from adrenal zona glomerulosa cells by ANP is mediated by GC-A
- Garner-Hamrick, Peggy A., Karl Mathis, Tom Emmons, Michael A Tones
Binding of [ 3H]BAY 58-2667 to purified bovine lung soluble guanylate cyclase by scintillation proximity assay
- González, Marta, Gonzalo Costa, Ángeles García-Pascual, Domingo Triguero
Cyclic GMP-gated channels are co-localized with a population of Interstitial cells, but not with neuronal NOS, in the rat urethra
- Hallén, Katarina, Lars E. Gustafsson, N. Peter Wiklund
Nerveinduced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic GMP
- Hepp, Régine, Nicolas Gervasi, Ludovic Tricoire, Bertrand Lambolez, Danièle Tritsch, Pierre Vincent
Imaging of nitric oxide signalling in thalamic neurons
- Hirth-Dietrich, Claudia, Cristina Alonso-Alija, Michael Härter, Michael G. Hahn, Yvonne Keim, Frank Wunder, Andreas Knorr, Johannes-Peter Stasch
Antifibrotic effects of an sGC activator in rat models of liver fibrosis
- Kilic, Ana, Sevdalina Yurukova, Stepan Gambaryan, Thomas Renné, Ulrich Walter, Melanie Voss, Wolfgang Dostmann, Michaela Kuhn
Increased tissue expression and activity of cGMP-dependent protein kinase I in ANP-receptor (GC-A) - deficient mice
- Kirsch, Mark, Norbert Weissmann, Barbara Kemp-Harper, Friedrich Grimminger, Harald H.H.W. Schmidt
The phosphodiesterase 5 inhibitor, sildenafil, further augments the compensatory upregulation of NO-cGMP signalling in hypoxic pulmonary hypertension
- Klimenko, Oxana and Anna Matvienko
The influence of peroxynitrite on some blood indices
- Kruuse, Christina, Tejvir S Khurana, Sergei D Rybalkin, Steffen Birk, Ulla Engel, Lars Edvinsson, Jes Olesen
Phosphodiestrase 5 and effects of sildenafil on cerebral arteries from man and guinea pig
- Lakics, Viktor, Eric Karran, Frank G. Boess
Analysis of phosphodiesterase expression using quantitative real time PCR
- Lange, Alexander, Florian Müllershausen, Andreas Friebe, Doris Koesling
Desensitisation of NO/cGMP signalling in vascular and bronchial smooth muscle
- Langmesser, Sonja, Susanne Feil, Franz Hofmann, Robert Feil, Urs Albrecht
Inactivation of cGKI in the CNS causes adaptation defects in the circadian clock in mice
- Lukowski, Robert, Pascal Weinmeister, Annette Vogl, Susanne Feil, Michael Gotthardt, Joachim Herz, Steffen Massberg, Franz Hofmann, Robert Feil
Function of smooth muscle cGMP-dependent protein kinase type I in a mouse model of restenosis
- Lyamina, Nedezhda, V.N. Senchihin, Svetlana Lyamina
The NO level in young patients with arterial hypertension and metabolic disorders
- Marro, Martin L. and Adrian J. Hobbs
Characterisation of human α 1 and β 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells
- Martin, Emil, Vasanthi Jayaraman, James Kincaid, Ferid Murad
Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase
- Masuyama, Hiroyuki, Toshihiro Tsuruda, Johji Kato, Takuroh Imamura, Yujiro Asada, Johannes-Peter Stasch, Tanenao Eto
Beneficial effect of s oluble guanylate cyclase stimulator BAY 41-2272 on c ardiovascular remodeling in angiotensin II-induced hypertensive rats
- Matt, Simone, Sabine Meurer, Steffen Gross, Werner Müller-Esterl
Characterization of MRIP2 as a NO-sensitive guanylyl cyclase-associated protein
- Mergia, Evanthia, Andreas Friebe, Oliver Dangel, Michael Russwurm, Doris Koesling
Conditional inactivation of the NO-sensitive guanylyl cyclase isoforms (α 1, β 1, α 2, β 1) in mice
- Meurer, Sabine, Steffen Gross, Sylke Pioch, Werner Müller-Esterl
Tyrosine phosphorylation of NO-sensitive guanylyl cyclase
- Nedvetskaya, Tatiana Y., Pavel I. Nedvetsky, Sanchaita Sriwal Sonar, Helmut Müller, Albert Sickmann, Peter M. Schmidt, Petra Kronich, Johannes-Peter Stasch, Harald H.H.W. Schmidt
Formation of quasi-covalent sGC a 1 / b 1 -heterodimers by ODQ-induced oxidation of the prosthetic heme moiety
- Nimmegers, Sofie, Patrick Sips, Emmanuel Buys, Peter Brouckaert, Johan Van de Voorde
NO-mediated vascular smooth muscle relaxation in sGCα 1 knock-out mice
- Papapetropoulos, Andreas, Davina de C.M. Simoes, Georgia Xanthou, Charis Roussos, Christina Gratziou
Reduction of soluble guanylyl cyclase expression in asthma
- Pioch, Sylke, Sabine Meurer, Steffen Gross, Werner Müller-Esterl
Interaction of NO-sensitive guanylyl cyclase with Src-like kinases
- Postnikov, Alexander, Vasily Betin, Ferid Murad, Alexander Kots
Regulation of soluble guanylate cyclase activity by direct interaction with heat shock protein Hsp90
- Pullamsetti, Soni, Ladislau Kiss, Hossein Ardeschir Ghofrani, Robert Voswinckel, Peter Haredza, Walter Klepetko, Clemens Aigner, Ludger Fink, Jai Prakash Muyal, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension
- Pyriochou, Anastasia, Chris Polytarchou, Evangelia Papadimitriou, Andreas Papapetropoulos
Soluble guanylyl cyclase activation promotes angiogenesis
- Russwurm, Michael, Corina Wagner, Doris Koesling
NO-sensitive guanylyl cyclase: binding and dissociation of nitric oxide
- Sausbier, Matthias, Hong Zhao, Rudolf Schubert, Ulrike Sausbier, U Abdullah, Andrea Huber, Susi Feil, Robert Feil, Franz Hofmann, Winfried Neuhuber, Hans-Dieter Allescher, Peter Ruth
Enhanced vascular cGMP/cGK I signaling and hypotonia in cysteine-rich-protein 2-deficient mice
- Schmidt, Peter Manuel, Christiane Rothkegel, Frank Wunder, Friederike Stoll, Henning Schröder, Johannes‑Peter Stasch
Residues stabilizing the heme moiety of the NO sensor soluble guanylate cyclase
- Schmidtko, Achim, Irmgard Tegeder, Ellen Niederberger, Franz Hofmann, Peter Ruth, Gerd Geisslinger
The role of cGMP and PKG-I in spinal nociceptive processing
- Siednienko, Jakub, Małgorzata Ciuman, Hanna Witwicka, Wojciech A. Gorczyca
Activation of NF-κB by nitric oxide/cGMP in human blood CD14 + cells
- Sips, Patrick, Emmanuel Buys, Robrecht Thoonen, Anje Cauwels, Elke Rogge 1, Maureen Van Den Hemel, Mieke Dewerchin, Peter Brouckaert
Gender-specific hypertension in mice deficient in the alpha1 subunit of soluble guanylate cyclase
- Sonar, Sanchaita Sriwal, Thomas Eucker, Harald H.H.W. Schmidt The elusive b 2 subunit of sGC
- Tokuda, Harukuni, Fumio Enjo, Ayako Kumagai, Takao Konoshima, Midori Takasaki, Junko Takayasu, Hoyoku Nishino
Tumor initiating activity of NO donor in two-stage mouse skin carcinogenesis and its role of cGMP
- Torres, Magdalena, Sandra Jurado, Elena López, Francisco M. Reimunde, Santiago Lamas, Fernando Rodríguez-Pascual
NMDA treatment stabilizes the mRNA encoding for α 2 subunit of the NO-sensitive guanylyl cyclase by decreasing AUF1 protein level through a NO-cGMP-dependent mechanism
- Vanneste, Gwen, Ingeborg Dhaese, Patrice Sips, Emmanuel Buys, Peter Brouckaert, Romain A. Lefebvre
Role of soluble guanylate cyclase in NO-induced effects of gastric fundus
- Wagner, Corina, Michael Russwurm, Doris Koesling
NO-sensitive guanylyl cyclase: Identification and purification of the dimerization domain
- Wang, Yingrui, Stephanie Krämer, Tanja Loof, Sebastian Martini, Susanne Kron, Hiroshi Kawachi, Fuijo Shimizu, Hans-H. Neumayer, Harm Peters
Enhancing cGMP in anti-thy1-induced, chronic-progressive glomerulosclerosis: sGC stimulation versus PDEs inhibition
- Weber, Silke, Susanne Feil, Sabine Brummer, Anna-Maria Knorn, Franz Hofmann, Robert Feil
Knock-in mice expressing cGKIα or cGKIβ selectively in smooth muscle
- Wegener, Jörg W., Petra Smital, Jens Schlossmann, Franz Hofmann
IRAG is involved in cGMP/cGK-mediated relaxation of contractions induced by calcium entry
- Weidenbach, Andreas, Johannes-Peter Stasch, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Inhaled NO and the guanylate cyclase stimulator Bay 41-2272 in oleic acid induced acute lung injury in rabbits
- Weinmeister, Pascal, Robert Lukowski, Stefan Linder, Wolfgang Erl, Richard Brandl, Susanne Feil, Franz Hofmann, Robert Feil
Regulation of vascular smooth muscle growth by cyclic nucleotides and cGMP-dependent protein kinase
- Wörner, René, Robert Feil, Franz Hofmann, Jörg W. Wegener
Protein kinase A mediates 8-Br-cGMP-induced Ca 2+-desensitization in murine aorta
- Wunder, Frank, Adrian Tersteegen, Martin Hendrix
Characterization of the novel PDE9 inhibitor BAY 73-6691 using a cGMP reporter cell line
- Zhou, Zongmin, Christina Gerassimou, Richard C. Venema, Charis Roussos , William C. Sessa, John Catravas, Andreas Papapetropoulos
Interaction between hsp90 and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding
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