Program

Friday, June 19, 2009

 

14:00 Jens Schlossmann,
Regensburg		 Welcome to Regensburg
Session 1
Therapeutic Breakthroughs 		Chair:           Mihai Gheorghiade, Chicago
        Ferid Murad, Houston
14:10 John Burnett,
Rochester		 Modulating cGMP in heart failure by novel natriuretic peptides
14:35 John Parker,
Toronto 		Nitrate-induced toxicity and preconditioning
15:00 John Horowitz,
Adelaide		 Nitric oxide-resistance at the level platelet: pathophysiology and therapeutic implications
Session 2
cGMP and Cardiac Protection 		Chair:          Jim Downey, Mobile
       Johannes-Peter Stasch, Wuppertal
15:25 Jim Downey,
Mobile 		The role of cGMP and PKG in cardioprotection
15:50 Rakesh Kukreja,
Virginia
 Phosphodiesterase-5 inhibition and cardioprotection: potential role of hydrogen sulfide
16:15 Robert Lukowski,
München
 cGKI signaling in cardiac hypertrophy
16:40 David Kass,
Baltimore
 Novel mechanisms of anti-hypertrophic effects from PDE5A inhibition
 
17:05–17:30 COFFEE BREAK
 
Session 3
cGMP and Lung 		Chair:            Steve Abman, Aurora
         Robert Feil, Tübingen
17:30 Steve Abman,
Aurora 		Impaired NO-cGMP signaling in the pathogenesis of neonatal pulmonary hypertension and therapeutic implications
17:55 David Pearse,
Baltimore
Janus-faced signaling of cGMP in acute lung injury
18:20 Wolfgang Kübler,
Berlin
Yin and Yang of cGMP signalling in hydrostatic lung edema
18:45 Michael Mendelsohn,
Boston
 Cyclic GMP-dependent protein kinase regulation of airway smooth muscle in asthma
 
19:10–20:00 Session 4
Guided Posters		 SNACK & REFESHMENTS, WINE & BEER
Molecular Mechanisms Chair:            Soenke Behrends, Braunschweig

 

Heart/Lung Chair:           Guido Boerrigter, Rochester

 

Clinics/Biomarkers Chair:           Berthold Hocher, Berlin

 

 
Evening Lecture Chair:           John Burnett, Rochester
20:00–21:00 Mihai Gheorghiade,
Chicago		 Acute heart failure syndromes: new agents

 

Saturday, June 20, 2009

 

Session 5
sGC Structure and Function 		Chair:           Harald Schmidt, Melbourne
        Michael Marletta, Berkeley
08:00 Michael Marletta,
Berkeley

A molecular view of the regulation of sGC activity
08:25 Focco van den Akker,
Cleveland

Structural insights into sGC
08:50 Clemens Steegborn,
Bochum

Structural and mechanistic insights into cGMP signaling
09:15 Andreas Friebe,
Bochum

NO signalling in mice lacking the NO receptor guanylyl cyclase
09:40 Peter Brouckaert,
Ghent		 Phenotypes of sGC mutant mice in basic conditions, disease and shock
10:05–10:35 COFFEE BREAK
 
Session 6
cGKI and the Vascular System 		Chair:           Kazuwa Nakao, Kyoto
        Doris Kösling, Bochum
10:35 Franz Hofmann,
München
Rescue cGMP kinase I and cause of premature death
11:25 Philip Eaton,
London 		Redox regulation of protein kinase G
11:50 Peter Ruth,
Tübingen		 CRP4, a new effector of cGMP Kinase?
12:15 Jens Schlossmann,
Regensburg
 Functional dissection of the cGK substrate IRAG using transgenic models
12:40 Daisuke Taura,
Kyoto		 Cyclic GMP signalling in human ES and iPS-derived vascular cells
13:05 Ardeshir Ghofrani,
Giessen
 Riociguat dose titration in patients with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (PAH)
   
13:30–14:30 Session 7
Guided Poster Session 		SNACKS AND REFRESHMENTS AT THE POSTERS
Cardiorenal/
Urology		 Chair:           Gilberto De Nucci, Sao Paulo

 

CNS Chair:           Rohini Kuner, Heidelberg

 

Platelets/VSMC Chair:           Stepan Gambaryan, Würzburg

 

 
14:30–17:00 REGENSBURG VISIT
Guided walking tour through the historic Regensburg
 

Ferid Murad Lecture

 Chair:           Ferid Murad, Houston
18:00–19:00 John Beavo Cyclic nucleotide phosphodiesterases – 40 years of progress

 

Sunday, June 21, 2009

 

Session 8
Other Functions of cGMP 		Chair:           Franz Hofmann, München
        Ulrich Walter, Würzburg
08:00 Andreas Papapetropoulos,
Patras
Regulation of soluble guanylyl cyclase by phosphorylation
08:25 Frank Bozovich,
Rochester

cGMP effects on vascular tone: modulating the activity of myosin light chain phosphatase
08:50 Renate Pilz,
San Diego 		Role of PKG II in osteoblast mechanotransduction
09:15 Hiroshi Kawaguchi,
Tokio		 Cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth
09:40 Peter Sandner,
Wuppertal

cGMP elevation: new options for lower urinary tract disorders
10:05 Ulrich Walter,
Würzburg

Cross-talk of inhibitory and stimulatory signalling pathways of human platelets

10:30–11:00

 COFFEE BREAK
 
Session 9
cGMP regulated Ion Channels		 Chair:           Michael Mendelssohn, Boston
        Peter Ruth, Tübingen
11:00 Roland Stocker,
Sydney
 Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation
11:25

Benjamin Kaupp,
Bonn

 Forget cooperativity! Single molecule signalling with cGMP
11:50 Martin Biel,
München
 Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies
12:15 Frank Zufall,
Bad Homburg 		Receptor guanylyl cyclases in mammalian olfaction: from genes to function

12:40

Edward Ziff,
New York 		A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity
 
13:05–13:50
Session 10
Guided Poster Session 		SNACKS AND REFRESHMENTS AT THE POSTERS
NO/sGC/PKG Chair:           Andreas Friebe, Bochum

 

Natriuretic Peptides Chair:           Lincoln Potter, Minneapolis

 

Others Chair:           Andreas Papapetropoulos, Athen

 

 
Session 11
cGMP and Pain/Fear 		Chair:           Martin Biel, München
        Jens Schlossmann, Regensburg
13:50 Achim Schmidtko,
Frankfurt		 cGMP-dependent signaling pathways in spinal pain processing
14:15 Rohini Kuner,
Heidelberg		 Presynaptic cGMP-dependent protein kinase-I mediates synaptic potentiation in spinal amplification of pain
14:40 Thomas Kleppisch,
München		 Role of cGMP-dependent protein kinases for fear memory formation in the lateral amygdala
15:05 Ryuji Inoue, Fukuoka cGMP-mediated regulation of cardiovascular Ca2+ entry channel TRPC6 and its pathophysiological implications
15:30–16:00 COFFEE BREAK
 
Session 12
Hot Topics on cGMP		 Chair:           Günter Schultz, Berlin
        Bernd Mayer, Graz
16:00 David Baker,
London		 The role of the cGMP-dependent protein kinase in devolpment of the malaria parasite
16:25 Ulrich Förstermann,
Mainz 		Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity
16:50 Michaela Kuhn,
Würzburg		 The natriuretic peptide / guanylyl cyclase-A system functions as a stress-responsive regulator of angiogenesis in mice
17:15 Annie Beuve,
Newark 		Thiol-dependent redox modulation of soluble guanylyl cyclase
17:30 Jeson Sangaralingham,
Rochester 		Progressive decline in circulating CNP with aging is associated with progressive cardiac fibrosis and myocardial impairment
17:45 Robrecht Thoonen,
Gent 		NO-insensitive sGCbeta1 H105F knockin mice: if NO has no place to go
 
Session 13 Poster Prize Session Chair:          Barbara Kemp-Harper, Melbourne
       Adrian Hobbs, London
18:00–18:20 N.N. Each candidate may talk for 3 min and show up to 3 slides or overheads and allow for 2 min question time
 
 
Session 14 Committee Meetings  
18:20–18:40 Poster Prize Committee Selected out of poster presentations
  Young Investigator Award Selected out of all oral presentations
 
19:00
COCKTAIL AND DINNER AT FÜRSTLICHES BRAUHAUS
AWARD CEREMONY
AWARD DINNER
 
 

Poster Session
  
  1. Najla Arshad, Sandhya S Visweswariah
    Glycosylation of human receptor guanylyl cyclase C
  2. Reshma S Baliga, Sarah Trinder, Chris J Scotton, Rachel C Chambers, Raymond J MacAllister, Adrian J Hobbs
    Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension
  3. Matteo Beretta, Antonius C F Gorren, M Verena Wenzl, Robert Weis, Michael Russwurm, Doris Koesling, Kurt Schmidt, Bernd Mayer
    Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2
  4. Guido Boerrigter, Lisa C Costello-Boerrigter, Syed Ameenuddin, Douglas W Mahoney, Joshua P Slusser, Denise M Heublein, Margaret M Redfield, Richard J Rodeheffer, Timothy M Olson, John C Burnett Jr
    B-type natriuretic peptide single nucleotide polymorphism rs198389 and survival in the general community
  5. Emmanuel S Buys, Anje Cauwels, Michael J Raher, Jonathan J Passeri, Ion Hobai, Sharon M Cawley, Kristen M Rauwerdink, Helene Thibault, Patrick Y Sips, Robrecht Thoonen, Marielle Scherrer-Crosbie, Fumito Ichinose, Peter Brouckaert, Kenneth D Bloch
    sGCa1ß1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models
  6. Darren E Casteel, Eric V Smith-Nguyen, Banumathi Sankaran, Glen Spraggon, Eric N Hampton, Renate B Pilz, Susan S Taylor, Choel Kim
    The first crystal structure of cyclic GMP-dependent protein kinase I? dimerization/docking domain reveals molecular details of isoform-specific anchoring
  7. Horng H Chen, Alessandro Cataliotti, Fernando L Martin, John A Schirger, John C Burnett Jr
    Renal targeted protein therapeutics in experimental overt heart failure with renal dysfunction
  8. Horng H Chen, Brenda K Huntley, Alessandro Cataliotti, Fernando L Martin, John C Burnett Jr
    Mutation of three amino acids in the disulfide-ring of a CNP based chimeric natriuretic peptide alters its vascular properties
  9. Lisa C Costello-Boerrigter, Guido Boerrigter, Syed Ameenuddin, Douglas W Mahoney, Joshua P Susser, Denise M Heublein, Margaret M Redfield, Richard J Rodeheffer, Timothy M Olson, John C Burnett Jr
    B-type natriuretic peptide single nucleotide polymorphism rs198389 is highly prevalent and impacts test characteristics of common assays
  10. Kelly Decaluwé, Sofie Nimmegeers, Robrecht Thoonen, Peter Brouckaert, Johan Van de Voorde
    In vitro and in vivo studies on the importance of the soluble gyanylyl cyclase alpha 1 subunit in penile erection
  11. Matthias Desch, Katja Sigl, Jörg Wegener, Robert Feil, Susi Feil, Franz Hofmann, Jens Schlossmann
    Cardiovascular and gastrointestinal function of IRAG
  12. Deborah M Dickey, Andrea R Yoder, Lincoln R Potter
    ANP mutation causes reduced proteolysis
  13. Bakytbek Egemnazarov, Akylbek Sydykov, Ralph T Schermuly, Norbert Weissmann, Johannes-Peter Stasch, Werner Seeger, Friedrich Grimminger, Hossain A Ghofrani
    sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
  14. Darcy R Flora, Sean D Conner, Lincoln R Potter
    Internalization and degradation of natriuretic peptide receptor-A is stimulated by ligand binding
  15. Reiner Frey, Wolfgang Mück, Nina Kirschbaum, Jörn Krätzschmar, Gerrit Weimann, Georg Wensing
    Warfarin pharmacodynamics and pharmacokinetics are not affected by the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)
  16. Martin Göttle, Frieder Kees, Roland Seifert
    Cytidylyl cyclase activity of bacterial exotoxins
  17. Martina Griesberger, Gerald Wölkart, Antonius Gorren, Matteo Beretta, Verena Wenzl, Juliane Brettschneider, Andreas Seeling, Jochen Lehmann, Michael Russwurm, Doris Koesling, Kurt Schmidt, Bernd Mayer
    Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase
  18. Dieter Groneberg, Doris Koesling, Andreas Friebe
    Evaluation of ODQ as specific inhibitor of NO-sensitive guanylyl cyclase using mice deficient for the enzyme
  19. Bianca Grosz, Stephanie Krämer, Tanja Loof, Hans-H Neumayer, Yingrui Wang-Rosenke, Harm Peters
    Blood pressure-independent effects of enhanced NO/cGMP signalling and gender on aortic remodelling in experimental renal hypertension
  20. Nadine Haase, Monika Seeanner, Tobias Haase, Soenke Behrends
    Lack of correlation between sGC subunit expression and sGC activity in cerebral development is due to non-heterodimerizing subunits in vivo
  21. Tobias Haase, Nadine Haase, Soenke Behrends
    Direct evidence for close proximity of catalytic and regulatory domains of heterodimeric sGC based on fluorescence resonance energy transfer
  22. Michael Hartmann, Katharina Völker, Birgit Gaßner, Juliane Schröter, Beatrice Dankworth, Thomas Müller, Viacheslav O Nikolaev, Michaela Kuhn
    A splice variant of the guanylyl cyclase-A receptor interferes with atrial natriuretic peptide (ANP) signaling
  23. Eva Heining, Raphaela Schwappacher, D Horbelt, Otmar Huber, Petra Knaus
    Crosstalk of cyclic GMP dependent kinase I and BMP signaling
  24. Arnau Hervera, Roger Negrete, Sergi Leánez, Olga Pol
    Lack of mechanical and thermal allodynia, and thermal hyperalgesia induced by peripheral neuropathic pain in NOS2 knockout mice
  25. Bernhard Hieke, Jens Schlossmann
    Subcellular distribution of cGMP signalling proteins in VSMCs of IRAG KO mice
  26. Linda Sarah Hoffmann, Peter Michael Schmidt, Yvonne Keim, Stefan Schaefer, Harald Schmidt, Johannes-Peter Stasch
    Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation
  27. Tomoko Ichiki, Brenda K Huntley, S Jeson Sangaralingham, Horng H Chen, John C Burnett Jr
    A novel designer natriuretic peptide CD-NP suppresses TGF-beta 1 induced collagen Type I production in human cardiac fibroblasts
  28. Ronald Jäger, Corina Russwurm, Doris Koesling, Michael Russwurm
    GAF domain-induced activation of phosphodiesterases 2 and 5
  29. Emma S Jones, Barbara K Kemp-Harper, Johannes-Peter Stasch, Harald HHW Schmidt, Robert E Widdop
    Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension
  30. Philipp Kalk, Yuliya Sharkovska, Bettina Lawrenz, Michael Godes, Linda Sarah Hoffmann, Kathrin Wellkisch, Sandra Geschka, Katharina Relle, Berthold Hocher, Johannes-Peter Stasch
    Cardio-renal protection of riociguat (BAY 63-2521) in low- and high-renin models of hypertension
  31. Barbara Kemp-Harper, Ravina Ravi, Michelle Bullen, Rebecca Ritchie, Christopher Sobey, Alyson Miller
    Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase
  32. Hideyuki Kinoshita, Koichiro Kuwahara, Ryuji Inoue, Motohiro Nishida, Hitoshi Kurose, Shigeki Kiyonaka, Yasuo Mori, Masaki Harada, Masao Murakami, Yasuaki Nakagawa, Shinji Yasuno, Satoru Usami, Masataka Fujiwara, Yoshihiro Kuwabara, Takeya Minami, Yuko Yamada, Kenji Ueshima, Kazuwa Nakao
    Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway
  33. Ichiro Kishimoto, Takeshi Tokudome, Hideki Chusho, Kazuwa Nakao, Kenji Kangawa
    C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons
  34. Michael Klaiber, Katharina Völker, Birgit Gaßner, Andrea Gerling, Susanne Feil, Robert Feil, Michaela Kuhn
    The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts Angiotensin II-stimulated calcium mobilization in cardiac myocytes
  35. Sevil Korkmaz, Tamás Radovits, Eniko Barnucz, Kristóf Hirschberg, Philipp Neugebauer, Sivakkanan Loganathan, Stefan Zöllner, Szabolcs Páli, Beatrice Seidel, Matthias Karck, Gábor Szabó
    Pharmacological activation of soluble guanylate cyclase activator protects the heart against isoproterenol-induced myocardial ischemia in rats
  36. Thomas Krieg, Yanping Liu, Thomas Rütz, Carmen Methner, Xi-Ming Yang, Stephan B Felix, James M Downey
    BAY 58-2667, an NO-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts
  37. Martina Krüger, Sebastian Kötter, Anika Grützner, Patrick Lang, Christian Andresen, Margaret M Redfield, Elke Butt, Cris G dos Remedios, Wolfgang A Linke
    Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs
  38. Christina Kruuse, Saurabh Gupta, Elisabet Nilsson, Lars Kruse, Lars Edvinsson
    Differential effects of selective PDE5 inhibitors in rat cerebral arteries in vitro and in vivo
  39. Emmanuelle Laffly, Jane Macdonald, Elsa Garcin
    From biochemical and structural studies of soluble guanylate cyclase toward drug design
  40. Veronika Leiss, Andreas Friebe, Franz Hofmann, Robert Lukowski
    cGMP kinase I regulates glucagon release
  41. Sivakkanan Loganathan, Tamás Radovits,,Kristóf Hirschberg, Sevil Korkmaz, Matthias Karck, Gábor Szabó
    Phosphodiesterase-5 inhibition delays cardiac dilation and improves myocardial function in a rat model of heart failure due to chronic volume overload
  42. Yan Luo, Olivia Baessler, Mirko Glinski, Michael Sefkow, Mathias Dreger, Hubert Koester
    Identification of novel target proteins of cGMP/cAMP signaling pathway using cGMP/cAMP capture compound mass spectrometry (CCMS)
  43. Jane Macdonald, Emmanuelle Laffly, Elsa Garcin
    Structural studies of soluble guanylate cyclase
  44. Fima Macheret, Denise Heublein, Brian Lahr, Lisa Costello-Boerrigter, Guido Boerrigter, Paul McKie, Sharon Sandberg, Richard Rodeheffer, Alessandro Cataliotti, John C Burnett Jr
    Pro-B-Type natriuretic peptide: a novel, specific biomarker for detection of left ventricular dysfunction in the general community
  45. Antonia Marazioti, Padmamalini Baskaran, Annie Beuve, Carlos Romao, Anastasia Pyriochou, Andreas Papapetropoulos
    Effects of carbon monoxide-releasing molecules on cGMP levels and soluble guanylate cyclase activity
  46. Jens Martens-Lobenhoffer, Christin Dautz, Stefanie M Bode-Böger
    Quantification of cGMP in human plasma by isotope dilution LC-MS/MS
  47. Björn KI Meijers, Constanze Meye, Johannes-Peter Stasch, Peter Gross, Pieter Evenepoel
    The uremic retention solute p-cresyl sulfate alters NO signal transduction by alteration of the soluble guanylate cyclase redox state
  48. Evanthia Mergia, Johannes Stegbauer, Sebastian Friedrich, Ivo Quack, Lars Christian Rump, Doris Koesling
    Negative feedback regulation within NO/cGMP pathway attenuates vasodilatory response in renovascular hypertension
  49. Sabine Meurer, Sylke Pioch, Tatjana Pabst, Nils Opitz, Peter M Schmidt, Tobias Beckhaus, Kristina Wagner, Simone Matt, Kristina Gegenbauer, Sandra Geschka, Michael Karas, Johannes-Peter Stasch, Harald HHW Schmidt, Werner Müller-Esterl
    Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteosomal degradation
  50. Thomas W Miller, Jeff S Isenberg, David D Roberts
    Thrombospondin-1 is a universal inhibitor of soluble guanylate cyclase activation
  51. Veselin Mitrovic, B Swidnicki, Ardeschir Ghofrani, Wolfgang Mück, Nina Kirschbaum, Joachim Mittendorf, Johannes-Peter Stasch, Georg Wensing, Reiner Frey, Silvia Lentini
    Acute hemodynamic response to single oral doses of BAY 60-4552, a soluble guanylate cyclase stimulator, in patients with biventricular heart failure
  52. Joachim Mittendorf, Stefan Weigand, Cristina Alonso-Alija, Erwin Bischoff, Achim Feurer, Michael Gerisch, Armin Kern, Andreas Knorr, Dieter Lang, Klaus Muenter, Martin Radtke, Hartmut Schirok, Karl-Heinz Schlemmer, Elke Stahl, Alexander Straub, Frank Wunder, Johannes-Peter Stasch
    Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
  53. Candace M Parchen, Dao-Fu Dai, Justin M Percival, Monte Willis, Stanley C Froehner, Joseph A Beavo
    Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice
  54. Fernanda B M Priviero, Julio A Rojas-Moscoso, Alexandre S Silva, Edson Antunes, Angelina Zanesco
    Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats
  55. Anastasia Pyriochou, Athanasios Giannis, Andreas Papapetropoulos
    Synthesis and characterization of NS-2028 analogues
  56. Tamás Radovits, Sevil Korkmaz, Sivakkanan Loganathan, Johannes-Peter Stasch, Matthias Karck, Gábor Szabó
    Pharmacological preconditioning with the guanylate cyclase activator cinaciguat (BAY 58-2667) protects against reperfusion injury after cardiopulmonary bypass
  57. Kerstin Rauch, Johannes-Peter Stasch, Volkhard Kaever, Roland Seifert
    Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase
  58. Rebecca Ritchie, Jennifer Irvine, Swati Gossain, Jane Love, John Horowitz, Barbara Kemp-Harper
    The novel NO redox sibling, nitroxyl (HNO), prevents cardiomyocyte hypertrophy and superoxide generation via cGMP
  59. Rebecca Ritchie, Jennifer Irvine, Jane Love, John Horowitz, Johannes-Peter Stasch, Barbara Kemp-Harper
    Antihypertrophic actions of NO-independent soluble guanylyl cyclase (sGC) ligands BAY 41-2272 and BAY 58-2667 in vitro
  60. Natalia Rukoyatkina, Ulrich Walter, Stepan Gambaryan
    NO inhibits platelet apoptosis by cGMP-dependent and-independent pathways
  61. Corina Russwurm, Georg Zoidl, Doris Koesling, Michael Russwurm
    The neuronal PDE2A3 splice variant is targeted to membranes via dual acylation
  62. Elisabeth Schinner, Jens Schlossmann
    NO/cGMP signalling in platelets
  63. John A Schirger, Horng H Che, Josh Slusser, David Hodge, Denise Heublein, Alessandro Cataliotti, Sharon Sandberg, John C Burnett Jr
    The degree of natriuretic peptide system activation in stable and high risk CHF characterized by increased cystatin C is not reflected in cGMP activation
  64. Hannes Schmidt, Agne Stonkute, René Jüttner, Doris Koesling, Andreas Friebe, Robert Feil, Franz Hofmann, Fritz G Rathjen
    C-type natriuretic peptide is a bifurcation factor for sensory neurons
  65. Christian Spangler, Roland Seifert, Volkhard Kaever
    Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
  66. Corinna M Spangler, Bettina Wilhelm, Heike Burhenne, Kerstin Rauch, Roland Seifert, Volkhard Kaever
    Sensitive assay for the detection of cyclic nucleotides by mass spectrometry
  67. Beate Spiessberger, Pascal Weinmeister, Franz Hofmann, Claudia Werner, Dieter Saur, Ursula Seidler, Wen Zheng, Jens Schlossmann, Robert Lukowski
    The role of cGMP-cGKI-signaling for duodenal bicarbonate secretion
  68. Haroldo A F Toque, Rafael P Morganti, Gilberto De Nucci, Edson Antunes
    Mechanisms of relaxant activity of BAY 41-2272 in rat tracheal smooth muscle in vitro
  69. Domingo Triguero, Maria Sancho, Marta García-Flores, Ángeles García-Pascual
    Blockade of CNG channels abrogates urethral relaxation induced by soluble guanylate cyclase activation
  70. Yutang Wang, Dechaboon Changsiri, Gavin McKenzie, Johannes-Peter Stasch, Michael Hahn, C Woolfe, D Rajbhandari, David S Celermajer; Roland Stocker
    Is kynurenine a novel and important vasodilator in human septic shock?
  71. Yingrui Wang-Rosenke, Dmytro Khadzhynov, Tanja Loof, Stephanie Krämer, Bogdan Iliev, Alice Mika, Hans-H Neumayer, Harm Peters
    Stimulation of soluble guanylate cyclase accelerates renal recovery following relief of unilateral ureteral obstruction
  72. M Verena Wenzl, Matteo Beretta, Antonius C F Gorren, Pravas K Baral, Karl Gruber, Michael Russwurm, Doris Koesling, Kurt Schmidt, Bernd Mayer
    Role of the general base Glu268 in nitroglycerin bioactivation and mechanism-based superoxide formation by aldehyde dehydrogenase-2
  73. Frank Wunder, Daniel Barufe, Annette Woermann, Markus Milde
    Pharmacological characterization of receptor guanylyl cyclase reporter cell lines
  74. Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, Eri Kondo, Naoaki Murao, Masako Miura, Naotetsu Kanamoto, Yasato Komatsu, Hiroshi Arai, Kazuwa Nakao
    Therapeutic potential of CNP for skeletal dysplasias
  75. Andrea R Yoder, Matthew D Stone, Tim Griffin, Lincoln R Potter
    Determination of new phosphorylation sites within natriuretic peptide receptors using mass spectrometric methods
  76. Andrea R Yoder, Kathryn A Barbieri, Jerid W Robinson, Lincoln R Potter
    Possible identification of novel natriuretic peptide receptor phosphorylation sites by alanine/glutamate mutagenesis
  77. Angelina Zanesco, Maria A Delbin, Ana P C Davel, Fernando R Bau, Fernanda B M Priviero, Luciana V Rossoni, Edson Antunes
    Effect of exercise training on endothelium-dependent relaxing response and cGMP concentration in pulmonary artery from rats submitted to lung ischemia/reperfuion
  78. Angelina Zanesco, Fernanda M B Priviero, Julio A Rojas-Moscoso, Alexandre S Silva, Edson Antunes
    L-arginine supplementation improves aortic vascular relaxation via NO-independent sGC/cGMP signaling in exercised rats
  79. Tong Zhang, Raphaela Schwappacher, Shunhui Zhuang, Renate B Pilz
    Regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
  80. Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, David Fulton, Annie Beuve, Andreas Papapetropoulos
    Regulation of soluble guanylyl cyclase by phosphorylation