Program

Friday, June 24, 2011

 

Opening Ceremony
14:00		 Reinhard Neubert,
Halle
Gunnar Berg,
Halle 		Welcome to Halle (Saale)
Greetings from the Leopoldina Nationale Akademie der Wissenschaften
Session 1
Therapeutic Breakthroughs 		Chair:           Mihai Gheorghiade, Chicago
          Johannes-Peter Stasch, Wuppertal
14:15 Kazuwa Nakao,
Kyoto 		Translational Science of the CNP/GC-B/cGMP System
14:40

 

 John Burnett,
Rochester		 Modulating cGMP in heart failure by novel natriuretic peptides: clinical results

15:05

 Jürgen Behr,
Bochum		 New clinical results with sGC stimulators

15:30

Martin Lefkowitz,
East Hanover

LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure and hypertension
Session 2
cGMP in Cardio-Vascular Disease 		Chair:          Kazuwa Nakao, Kyoto
         John Burnett, Rochester
15:55 Alan Maisel,
Chicago		 Biomarkers in kidney and heart disease
16:20

John D Parker,
Toronto

Sustained' use of GTN and ischemic preconditioning
16:45

Christopher Newton-Cheh, Boston

 Human genetics, natriuretic peptides and hypertension
17:10 Marco Guazzi,
Milan

Benefits of chronic PDEV inhibition in patients with diastolic heart failure
 
17:35–17:55 COFFEE BREAK
 
Session 3
cGMP and Lung 		Chair:            James Klinger, Providence
           Andreas Papapetropoulos, Patras
17:55 Marc Gladwin,
Pittsburgh		 Hemolysis-mediated endothelial dysfunction: role of NO and sGC activators
18:20 Michael Wolin,
New York    		Redox regulation of responses to hypoxia and NO-cGMP signalling in pulmonary vascular pathophysiology
18:55 Oleg Evgenov,
Boston  		Nitric oxide-independent stimulation of soluble guanylate cyclase attenuates pulmonary fibrosis
 
19:20–20:15
Session 4
Guided Poster Session 		SNACK & REFESHMENTS, WINE & BEER
Molecular Mechanisms Chair:            Soenke Behrends, Braunschweig

 

Heart/Lung Chair:           Oleg Evgenov, Boston

 

Clinics/Biomarkers Chair:           Guido Boerrigter, Rochester

 

 
Evening Lecture Chair:           Harald Schmidt, Maastricht
20:15–21:15 Paul Vanhoutte,
Hong Kong 		Endothelial dysfunction and vascular disease.

 

Saturday, June 25, 2011

 

Session 5
sGC Structure and Function 		Chair:           Michael Marletta, Berkeley
          Franz Hofmann, München
08:30 Michael Marletta,
Berkeley   		 A molecular view of the regulation of sGC activity
08:55 Focco van den Akker,
Cleveland  

Structural insights into sGC activation by different sGC activators
09:15 Susan Taylor,
San Diego		 PKA: assembly of dynamic macromolecular signalling
09:40 Wolfgang Dostmann,
Burlington		 Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication
10:05 Choel Kim,
Houston		 The crystal structures of PKG Iß (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding
10:30–11:00 COFFEE BREAK
 
Session 6
cGKI and Cardio-Vascular System 		Chair:           Michael Mendelsohn, New Yersey
          Doris Kösling, Bochum
11:00 Peter Brouckaert,
Gent		 Apo sGC mice: NO-independent role for sGC and sGC independent role for NO
11:25 Thomas Krieg,
Cambridge		 Characterization of mice with a deletion of cGKI in cardiomyocytes and the effect on cardioprotection through either postconditioning or mitochondria-targeted S-nitrosothiol
11:50   Alessandro Cataliotti,
Rochester

Long-term cardiac pro-BNP gene delivery prevents the development of hypertensive heart disease in SHR
12:15   Jens Schlossmann,
Regensburg		 Vascular and renal function of cGMP signalling
12:40 Eiki Takimoto,
Baltimore		 cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
13:05 Enrico Patrucco,
München 		cGMP kinase I, cardiac hypertrophy and PDE inhibition
   
13:30–14:30
Session 7
Guided Poster Session 		SNACKS AND REFRESHMENTS AT THE POSTERS
Cardiorenal/
Urology		 Chair:           Peter Sandner, Wuppertal

 

Platelets/VSMC Chair:           Andreas Papapetropoulos, Patras

 

Other Functions of cGMP Chair:           Alexander Pfeifer, Bonn

 

 
15:00–16:00 ORGAN RECITAL
Irénée Peyrot in the Marktkirche, Halle
16:00–18:00 Halle VISIT
Guided walking tour through the historic Halle
 
18:00–20:00 SNACKS AND REFRESHMENTS AT THE POSTERS
 

Ferid Murad Lecture

 Chair:           Ferid Murad, Washington
20:00–21:00 Michael Mendelsohn, New Jersey Halle-luja: Eine Kleine Nachtmusik about cGMP signalling in blood vessels

 

Sunday, June 26, 2011

 

Session 8
Other Functions of cGMP 		Chair:           Ikuo Tooyama, Otsu
          Romain Lefebvre, Ghent
08:30 Joseph Beavo,
Seattle		 Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?
08:55 Doris Koesling,
Missouri		 NO signalling in synaptic transmission
09:15 Philip Eaton,
London		 High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIɑ knock-in mouse
09:40 Takaaki Akaike,
Kumamoto		 Cellular signalling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide
10:05 Renate Pilz,
La Jolla		 Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex

10:30–11:00

 COFFEE BREAK
 
Session 9
cGMP and Ion Channels		 Chair:           Gilberto De Nucci, Sao Paulo
          Jens Schlossmann, Regensburg
11:00 Jörg Wegener,
München		 cGMP/cGKI signalling in peripheral VSM does not involve TrpC3 or TrpC6 channels
11:25 Gilberto De Nucci,
Sao Paulo		 Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of rattlesnake corpus cavernosum
11:50 Andreas Papapetropoulos,
Patras

Regulation of vascular growth and tone by hydrogen sulfide
12:15 Michaela Kuhn,
Würzburg

A novel pathway of cGMP
 
12:40–14:00
Session 10
Guided Poster Session 		SNACKS AND REFRESHMENTS AT THE POSTERS
NO/sGC/PKG Chair:           Harald Schmidt, Maastricht

 

Natriuretic Peptides Chair:           Michaela Kuhn, Würzburg

 

Other cGMP Topics Chair:           Roland Seifert, Hannover

 

 
Session 11
cGMP and Anti-Proliferation 		Chair:           Ferid Murad, Washington
          Vicente Felipo, Valencia
14:00 Vicente Felipo,
Valencia		 cGMP modulates stem cells differentiation to neurons in brain in vivo: pathological implications
14:25 Ikuo Tooyama,
Otsu		 BNP signalling is crucial for embryonic stem cell proliferation
14:50 Ronald Fiscus,
Henderson		 Protein kinase G type-I phosphorylates c-Src at serine-17 and promotes cell survival, proliferation and attachment in human mesothelioma and non-small cell lung cancer cells
15:15–15:45 COFFEE BREAK
 
Session 12
Upcoming Topics		 Chair:           Günter Schultz, Berlin
          Robert Lukowski, Tübingen
15:45 William Durante,
Missouri		 Vasoprotection by heme oxygenase-1: interactions with sGC
16:10 Annie Beuve,
Newark		 NO resistance in Angiotensin II-induced hypertension is associated with S-nitrosation of soluble guanylyl cyclase
16:50 Roland Seifert, Hannover Cyclic CMP and cyclic UMP: new (old) second messengers
17:15

Alexander Pfeifer,
Bonn

 Role of cGMP/PKG in fat tissue
 
Session 13
Poster Prize
Session		 Chair:          Adrian Hobbs, London
         Annie Beuve, Newark
17:40–18:00 N.N. Each candidate may talk for 3 min and show up to 3 slides or overheads and allow for 2 min question time
 
 
Session 14 Committee Meetings  
18:00–18:20 Poster Prize Committee Selected out of poster presentations
  Young Investigator Award Selected out of all oral presentations
 
19:00

20:00
GUIDED TOUR THROUGH ART COLLECTION MORITZBURG
COCKTAIL AND DINNER AT MORITZBURG
AWARD CEREMONY
FAREWELL PARTY
 

Poster Session
  

    Molecular Mechanisms

  1. Dieter Müller, Hanna Höfeld, Fritz Buck, Ralf Middendorff
    A novel natriuretic peptide-degrading protease in human lung
  2. Christian Krawutschke, Doris Koesling, Michael Russwurm
    cGMP signals in smooth muscle cells and cardiac myocytes
  3. Lise Román Moltzau, Jan Magnus Aronsen, Silja Meier, Cam Nguyen, Geir Christensen, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Eirik Qvigstad
    The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle
  4. Dieter Müller, Mirjam Hildebrand, Jörn Lübberstedt, Ralf Middendorff
    Tissue- and development-specific glycosylation states of the natriuretic peptide receptors guanylyl cyclase-A (GC-A) and GC-B
  5. Brent W Osborne, Andrew T Menke, Donald K Blumenthal, Wolfgang R Dostmann
    A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Ia
  6. Filipa Mota Quinteiro, Paul Gane, Anne-Sophie Rebstock, Roberta Worthington, Michela Simone, Snezana Djordevic, Adrian Hobbs, David Selwood
    Design and development of novel non-peptide agonists at NPR-C
  7. Nadiia Rozmaritsa, Torsten Christ, Erich Wettwer, Ursula Ravens
    NO-donors induce cross talk between cGMP and cAMP in signalling to human atrial L-type Ca2+ current
  8. Irina G Rybalkina, Masami Shimizu-Albergine, Sergei D Rybalkin
    Calcium/Calpain mediated regulation of cyclic nucleotide phosphodiesterases, PDE3A and PDE5, in human platelets
  9. Raphaela Schwappacher, Thuan Diep, Gerry Boss, Renate Pilz
    cGMP and PKGI are required for vascular BMP signaling

    10.  

    Heart/Lung

  10. Eva Maria Becker, Johannes-Peter Stasch, Martin Bechem, Hubert Truebel
    Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on "desaturation"
  11. Justin S Bice, Gary F Baxter
    Targeting of soluble guanylyl cyclase limits infarct size in a model of acute myocardial infarction
  12. Robert M Blanton, Eiki Takimoto, Angela Lane, Mark J Aronovitz, Richard H Karas, David A Kass, Michael E Mendelsohn
    Protein kinase G I alpha activates an anti-remodeling signaling pathway in the heart via an interaction with the MAPKKK mixed lineage kinase 3
  13. Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Johannes-Peter Stasch, John C Burnett, Jr
    Activation of heme-free soluble guanylate cyclase with cinaciguat has beneficial cardiorenal actions when added to furosemide in experimental heart failure
  14. Peter König, Dieter Groneberg, Roland Jäger, Andreas Friebe
    NO-sensitive guanylyl cyclase is expressed in pericytes but absent from endothelial cells in the murine lung
  15. Baktybek Kojonazarov, Michaela Lang, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani
    Effects of riociguat in severe experimental pulmonary hypertension
  16. Nils Kronas, Birte Peters, Alwin E Goetz, Jens C Kubitz
    Inhaled and intravenous application of a stimulator of the soluble guanylate cyclise (BAY 41-8543) reduces pulmonary vascular resistance in a model of septic shock
  17. Michaela Lang, Baktybek Kojonazarov, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Schermuly
    The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
  18. Silja Meier, Jan Magnus Aronsen, Ivar Sjaastad, Finn Olav Levy, Tor Skomedal, Jan-Bjørn Osnes, Eirik Qvigstad
    Cyclic GMP generated by natriuretic peptide receptor B enhances ß1-adrenoceptor signaling in normal and failing hearts

    19.  

    Clinics/Biomarkers

  19. Guido Boerrigter, Lisa C Costello-Boerrigter, Gail J Harty, John C Burnett, Jr.
    Bioavailability of intravenous versus subcutaneous administration of the dual GC-A and GC-B designer natriuretic peptide cenderitide in healthy canines
  20. Reiner Frey, Wolfgang Mück, Sigrun Unger, Michael Reber, Jörn Krätzschmar, Corina Becker, Georg Wensing
    No pharmacodynamic (PD) and pharmacokinetic (PK) interaction of riociguat (BAY 63-2521) and aspirin
  21. Reiner Frey, Wolfgang Mueck, Michael Becka, Joern Kraetzschmar, Georg Wensing
    Antiplatelet effects of aspirin are not affected by the soluble guanylate cyclase activator cinaciguat (BAY 58-2667)
  22. Julia Grupe, Andrea Neumann, Johannes-Peter Stasch, Kirsten Leineweber
    Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance
  23. Jeson S Sangaralingham, Denise M Heublein, Joseph P Grande, Alessandro Cataliotti, Andrew D Rule, Paul M McKie, Fernando L Martin, John C Burnett Jr
    C-Type Natriuretic Peptide: a potential urinary biomarker for renal remodeling and fibrosis during aging
  24. Christian Scheerans, Martin Blunck, Wolfgang Mueck, Reiner Frey
    Pharmacokinetic analysis of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in individuals with renal impairment compared to healthy controls
  25. Markus Schwefer, Aleksandra Mandecka, Helen Schmicker-Helf, Andreas Brückmann, Thomas Lehmann, Ingeburg Schauer, Frank Kramer, Marcus Blum, Harald Lapp
    Dynamic Vessel Analyzer (DVA) – a new method to detect endothelial dysfunction in chronic heart failure: correlation between DVA and asymmetric dimethyl arginine (ADMA)
  26. Yuichi Tamura, Tomohiko Ono, Takashi Kawakami, Masaharu Kataok, Motoaki Sano, Toru Satoh, Keiichi Fukuda
    Arterial methemoglobin level predicts therapeutic effectiveness of the PDE5 inhibitors in patients with in idiopathic pulmonary arterial hypertension

    27.  

    Cardiorenal/Urology

  27. Markus Alter, Ina Ott, Karoline von Websky, Oleg Tsuprykov, Yuliya Sharkovska, Katharina Krause-Relle, Jens Raila, Andrea Henze, Axel Kretschmer, Johannes-Peter Stasch, Berthold Hocher
    Additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone
  28. Caroline Feuerstacke, Sabine Tasch, Johanna Volkmann, Dieter Müller, Ralf Middendorff
    PDE expression and contractility of seminiferous tubules of the human testis
  29. Sandra Geschka, Axel Kretschmer, Yuliya Sharkovska, Oleg V Evgenov, Andreas Hucke, Bettina Lawrenz, Berthold Hocher, Johannes-Peter Stasch
    Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats
  30. Ilia Goltsman, Elena Ovcharenko, Aaron Hoffman, Giora Feuerstein, Zaid Abassi, Joseph Winaver
    Rosiglitazone improves the natriuretic response to atrial natriuretic peptide in rats with experimental congestive heart failure: possible involvement of a post-guanylate cyclase mechanism
  31. Dieter Groneberg, Peter König, Andreas Friebe
    Fertility in male mice lacking NO-sensitive guanylyl cyclase
  32. Andrea Mietens, Caroline Feuerstacke, Sabine Tasch, Gerrit Eichner, Ralph Theo Schermuly, Friedrich Grimminger, Dieter Müller, Ralf Middendorff
    Acute effects of phosphodiesterase 5 (PDE5) inhibition, ANP and NO on epididymal contractility are preserved despite chronic PDE5 exposure
  33. Dieter Müller, Michail S Davidoff, Ralf Middendorff
    Distinct ageing- and androgen-dependent effects on cGMP signalling proteins in three male rat urogenital organs (bladder, prostate, epididymis)
  34. Alexandra Oudot, Delphine Behr-Roussel, Sarah Poirier, Jacques Bernabé, Peter Sandner, François Giuliano
    Experimental evidence that a combination of sGC stimulator BAY 60-4552 and PDE5 inhibitor vardenafil could salvage ED-patients with insufficient response to PDE5 inhibitors after cavernous nerve injury
  35. Elisabeth Schinner, Armin Kurtz, Franz Hofmann, Jens Schlossmann
    Suppression of kidney fibrosis by cGMP-dependent protein kinase I

    36.  

    Platelets/VSMC

  36. Emmanuel S Buys, Michael J Raher, Andrew Kirby, Sarah R Hayton, Laurel T Tainsh, Patrick Y Sips, Peter Brouckaert, Mark J Daly, Kenneth D Bloch
    Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase ?1 deficient mice
  37. Stepan Gambaryan, Elke Butt, Joerg Geiger, Suzanne M Lohmann, Ulrich Walter
    Specific PKG inhibitors: do they really exist?
  38. Steven A Fisher, Ylva Mende, Brunhilde Wirth, Kang Fu
    Transformer (Tra2ß): master regulator of myosin phosphatase alternative splicing and smooth muscle responses to NO/cGMP signaling
  39. Claudia Heine, Nico Scherf, Katja Sygnecka, Ute Egerland, Thorsten Hage, Heike Franke
    Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model
  40. Ronald Jäger, Dieter Groneberg, Andreas Friebe
    Role of NO/cGMP signalling in VEGF-mediated angiogenesis
  41. Katharina Salb, Elisabeth Schinner, Jens Schlossmann
    Function of IRAG and the phosphorylation of the InsP3R-I for the NO/cGMP-dependent inhibition of platelet aggregation
  42. Kathrin Schulte, Doris Koesling, Evanthia Mergia
    Does a reduction of vascular relaxation promote hypertension?
  43. Samantha Yuen, Ozgur Ogut, Frank V Brozovich
    Differential phosphorylation of LZ+/LZ- MYPT1 isoforms by PKGI?: implication for vascular reactivity

    44.  

    Other Functions of cGMP

  44. Emmanuel S Buys, Yu-Chieh Ko, Sarah Hayton, Alexander Jones, Laurel Tainsh, Ruiyi Ren, Andrea Giani, Emma Abernathy, Haiyan Gong, Douglas J Rhee, Peter Brouckaert, Meredith Gregory, Louis R Pasquale, Kenneth D Bloch, Bruce Ksander
    sGCa1-deficient mice: a novel murine model of spontaneous primary open angle glaucoma
  45. Sarah Cosyns, Johannes-Peter Stasch, Peter Brouckaert, Romain A Lefebvre
    Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice
  46. Katja Jennissen, Bodo Haas, Wolfram S Kunz, Alexander Pfeifer
    cGMP and cAMP differentially regulate differentiation and function of brown adipocytes
  47. Christina Kruuse, Saurabh Gupta, Elisabeth Nilsson, Lars Kruse, Lars Edvinsson
    Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries – relevant to migraine?
  48. Caitlin J McFarland, Christian K Nickl, Brent W Osborne, Indra Neil Sarkar, Wolfgang R Dostmann
    cGMP-dependent protein kinase from Toxoplasma gondii: functional expression in E. coli and molecular characterization
  49. Michaela M Mitschke, Daniela Scholz, Katrin Zimmermann, Peter Mayer, Bodo Haas, Alexander Pfeifer, Ana Kilic
    Protein kinase G is a key regulator of murine white adipogenesis
  50. Isabel Schönle, Angela Neitz, Thomas Mittmann, Doris Koesling, Evanthia Mergia
    PDE2, a component of the NO/cGMP signalling in the hippocampus
  51. Beate Spiessberger, Dieter Saur, Ursula Seidler, Anurag K Singh, Robert Lukowski, Franz Hofmann
    The role of cGMP-cGKI-signaling for duodenal bicarbonate secretion
  52. Amparo Urios, ML Garcia-Torres, Carla Gimenez-Garzó, Cristina Aguado, Juan A del Olmo, Carmen Marin, Miguel Civera, Fernández N Cassinello, José Ortega, Antonio Ferrandez, J. Martinez-Valls, Miguel A Serra, José M Rodrigo, Vicente Felipo, Carmina Montoliu
    Metabilism of cyclic GMP in nonalcoholic fatty liver disease in morbid obesity

    53.  

    NO/sGC/PKG

  53. Sönke Behrends, Mareike Busker, Nadine Haase, Tobias Haase, Jan Krähling, Monika Linnenbaum
    Conjoined NO-sensitive guanylyl cyclases
  54. Kerstin Yvonne Beste, Johannes-Peter Stasch, Volkhard Kaever, Roland Seifert
    Evidence for two catalytic centers and Mn2+ as physiological cofactor of soluble guanylyl cyclase
  55. Swati Chauhan, Iraida Sharina, Emil Martin
    G-protein regulator LGN inhibits the activity of soluble guanylyl cyclase
  56. Kelly Decaluwé, Bart Pauwels, Sara Verpoest, Robrecht Thoonen, Emmanuel Buys, Peter Brouckaert, Johan Van de Voorde
    Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation
  57. Dorota Gryko, Emil Martin
    New vitamin B12 derivatives activates sGC
  58. Wiebke Janssen, Yves Schymura, Astrid Wietelmann, Johannes-Peter Stasch, Himal Luitel, Norbert Weissmann, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Thomas Braun, Werner Seeger, Ralph Theo Schermuly
    Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice
  59. Michael Sobolevsky, Swati Chauhan, Iraida Sharina, Emil Martin
    Gemfibrozil as a potential heme-independent sGC activator
  60. Robrecht Thoonen, Haihua Zhang, Yuichi Abe, Heather Nickerson, Mark Aronovitz, Pierre Chambon, Richard H Karas, Michael E Mendelsohn
    Smooth muscle cell specific deletion of the PKGIa target RGS2 induces vascular dysfunction and hypertension
  61. Byung-Kuk Yoo, Isabelle Lamarre, Jean-Louis Martin, Fabrice Rappaport, Michel Negrerie
    Dynamics of NO interacting with soluble guanylate cyclase from 1 ps to 0.1 s and induced structural transitions

    62.  

    Natriuretic Peptides

  62. Syed Ameenuddin, Elise A Oehler, John C Burnett Jr, Horng H Chen
    Treatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model
  63. Reshma S Baliga, Sarah L Trinder Christopher J Scotton, Rachel C Chambers, Raymond J MacAllister, Adrian J Hobbs
    Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis
  64. Wen Chen, Birgit Gaßner, Sebastian Börner, Michaela Kuhn
    Atrial natriuretic peptide increases the albumin permeability of mouse skeletal muscle microcirculation by the caveolae-mediated transcellular pathway
  65. Lisa C Costello-Boerrigter, Guido Boerrigter, Sarah Mangiafico, Alessandro Cataliotti, John C Burnett Jr
    The novel dual GC-A and GC-B designer natriuretic peptide, cenderitide (CD-NP), enhances the renal actions of furosemide in a model of severe heart failure
  66. Lisa C Costello-Boerrigter, John A Schirger, Wayne L Miller, Guido Boerrigter, Horng H Chen, Ruth Kempf, Candace Y Lee, John C Burnett Jr
    Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure
  67. Marina Dobrivojevic, Aleksandra Sindic, Bojana Nikitovic, Bayram Edemir, Eberhard Schlatter, Wolf-Georg Forssmann, Jochen R Hirsch
    Interaction between bradykinin and urodilatin - a possible mechanism of clinical relevance
  68. Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi, Russell Araki, Jennifer Villarreal, Glenmar Obedencio, Anne Kanta, Erik Sandvick, Craig Hill, Kevin Dement, Uwe Klein, Donavon McConn, William Martin, Sharath S Hegde
    Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension
  69. Fernando L Martin, Paul M McKie, S Jeson Sangaralingham, Tomoko Ichiki, Gerald E Harders, Horng H Chen, John C Burnett Jr
    Cenderitide, a novel dual GC-A and GC-B receptor activator, is a potent chronic cardiorenal fibroinhibiting peptide which suppresses aldosterone and reduces proteinuria in models of cardiorenal fibrosis
  70. Ronald Jäger, Corina Russwurm, Doris Koesling, Michael Russwurm
    Activation of PDE10 and PDE11

    71.  

    Other cGMP Topics

  71. Nirmalya Basu, Sayanti Saha, Sandhya S Visweswariah
    Signaling via guanylyl cyclase C: cGMP, Src and p21
  72. Heike Burhenne, Kim Tappe, Kerstin Beste, Ulrike Voigt, Corinna Spangler, Dimitrios Tsikas, Volkhard Kaever, Roland Seifert
    Quantitation of cyclic nucleotides in mammalian cells and in human urine by high-performance liquid chromatography/mass spectrometry
  73. Corina Russwurm, Ronald Jäger, Doris Koesling, Michael Russwurm
    Comparative analysis of PDE10A isoforms
  74. Barbara Lies, Dieter Groneberg, Dieter Saur, Peter König, Andreas Friebe
    Nitrergic relaxation of gastrointestinal smooth muscle: role of interstitial cells of Cajal and smooth muscle cells
  75. Robert S Stephens, Laura E Servinsky, David B Pearse
    cGMP-mediated antioxidant signaling: a role for the c-Abl tyrosine kinase
  76. Ulrike Voigt, Heike Burhenne, Lena Sonnow, Christine Wölfel, Corinna Spangler, Daniel Ladant, Dara W Frank, Volkhard Kaever, Roland Seifert
    The effector protein ExoY secreted by Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for GTP
  77. Katharina Werner, Frank Schwede, Hans-Gottfried Genieser, Jörg Geiger, Elke Butt
    Quantification of cAMP and cGMP analogs in intact cells: pitfals in enzyme immunoassays for cyclic nucleotides concentration in pulmonary artery from rats submitted to lung ischemia/reperfuion
  78. Sabine Wolter, Marina Golombek, Andreas Hammerschmidt, Frank Schwede, Hans-Gottfried Genieser, Roland Seifert
    Activation of cGMP-dependent protein kinase Ia and cAMP-dependent protein kinase A isoforms by cyclic nucleotides