8th International Conference on cGMP


cGMP: Generators, Effectors and
Therapeutic Implications

Preliminary program

Friday, June 23, 2017

13:00-14:00 Registration & Welcome Reception
14:00 Franz Hofmann
München
Welcome to Bamberg
Session 1
Therapeutic
Breakthroughs
Chairs:
Harald Lapp, Erfurt
Johannes-Peter Stasch, Wuppertal
14:10 Todd Milne
Boston
Second generation sGC stimulators & activators
14:30 Peter Sandner,
Wuppertal
sGC stimulators and the potential impact for the treatment of fibrotic diseases and systemic sclerosis
14:50 Steven Pullen,
Ridgefield
A soluble guanylate cyclase (sGC) activator is superior to a PDE5 inhibitor and a sGC stimulator in protecting from diabetic nephropathy in the ZSF1 rat
15:10 Henriette Andresen
Oslo
Identification and characterization of positive allosteric modulators of the natriuretic peptide receptor-A
15:25–15:55 COFFEE BREAK
Session 2:
cGMP signalling in cell growth and survival
Chairs:
Robert Feil, Tübingen
Franz Hofmann, München
15:55 Emmanuel Buys,
Boston
sGC and cardiovascular disease
16:15 Robert Lukowski,
Tübingen
Cardioprotective actions of the cGMP pathway in ischemia and reperfusion injury
16:35 Laurinda Jaffe,
Farmington
Intercellular signalling via cGMP diffusion through gap junctions restarts meiosis in ovarian follicles
16:55 Andreas Friebe,
Würzburg
NO/cGMP signalling in cells ‘off the beaten track’
17:15 Timothy Calamaras
Pittsburgh
Mixed lineage kinase 3 (MLK3), a novel PKGIα substrate, prevents pressure overload-induced cardiac remodelling
Murad Lecture Chair:
Ferid Murad, Washington DC
17:30 Ferid Murad
Washington DC
Introduction
17:35–18:35 Stefan Hell,
Göttingen
Optical microscopy: the resolution revolution
18:35-21:30
Poster Session 1
SNACKS, WINE AND BEER

Saturday, June 24, 2017

Session 3
Genetics
Chairs:
Michaela Kuhn, Würzburg
Peter Brouckaert, Ghent
08:30 Scott Waldman,
Philadelphia
GUCY2C mutations, colorectal cancer & obesity
08:50 Jeanette Erdmann,
Lübeck
sGC and atherosclerosis: a genomic approach
09:10 Henning Gall
Giessen
Whole genome sequencing of variants in GC-cGMP-PDE signalling in pulmonary hypertension
09:30 Stylianos Michalakis,
München
Gene therapy for CNGA3-linked achromatopsia: from mouse models to clinical trials
09:50 Ulrich Walter
Mainz
The human platelet phosphoproteome after sGC stimulation by Riociguat
10:05-10:35 COFFEE BREAK
Session 4
Presentations based on abstract submission
Chairs:
David Kass, Baltimore
Robert Lukowski, Tübingen
10:35 Ying-Chi Chao
Taipei
Guanylate cyclase-G is an alarm pheromone receptor in mice
10:50 James Klinger
Providence
The relationship between NO pathway biomarkers and response to riociguat in the RESPITE study of patients with PAH not reaching treatment goals with phosphodiesterase 5 inhibitors
11:05 Jaime Masferrer
Boston
The soluble guanylate cyclase stimulator, IW-1973, is efficacious in models of NASH and liver fibrosis
11:20 Dorit Möhrle
Tübingen
NO-sensitive guanylate cyclase isoforms NO-GC1 and NO-GC2 contribute to noise-induced inner hair cell synaptopathy
11:35 Sabine Tauscher
Würzburg
Cardiac natriuretic peptides improve pancreatic beta-cell function
11:50 Yasutake Tanaka
Osaka
ANP-GC-A signalling protects against acute exacerbation of pulmonary fibrosis in mice
12:05-13:30 SNACK AND REFESHMENTS
13:30-14:30 CHAMBER CONCERT BY THE BAMBERGER STREICHQUARTETT
Karmeliterkloster
14:30-16:30 BAMBERG VISIT
Guided city walk through historic Bamberg
16:30-17:00 COFFEE BREAK
Session 5
Non-cannonical signalling
Chairs:
Ulrich Walter, Mainz
Günter Schultz, Berlin
17:00 Amrita Ahluwalia,
London
The nitrate:nitrite:NO pathway: a reductionist approach
17:20 Nazareno Paolocci,
Baltimore
From Heaven to Heart: Nitroxyl (HNO) actions in the cardiovascular system
17:40 Philip Eaton,
London
Redox regulation of G-kinase
18:00 Adam Straub
Pittsburgh
Cytochrome b5 reductase 3 regulates soluble guanylate cyclase heme iron redox state
18:15-19:15 SNACKS AND REFRESHMENTS
Evening Lecture Chair:
Adrian Hobbs, London
19:15 Adrian Hobbs, London Introduction
19:20-20:00 Johannes-Peter Stasch,
Wuppertal
sGC stimulators and sGC activators: past, present and future
20:00-21:30
Poster Session 2
WINE AND BEER

Sunday, June 25, 2017

Session 6
G-Kinase structure and function
Chairs:
Philip Eaton, London
Doris Koesling, Bochum
08:30 Choel Kim,
Houston
The crystal structure of G-Kinase
08:50 Sonja Dames,
München
Insights in the regulation of mycobacterial G-kinase by redox changes, phosphorylation and membrane interactions by NMR
09:10 Nazha Hamdani,
Bochum
Titin as a promising target for cGMP/G-kinase and its potential role in heart failure
09:30 Robert Blanton,
Boston
Cardiac myosin binding protein-C as a substrate for G-kinase
09:50 Andrew Tobin,
Glasgow
Employing chemical genetics to determine the cellular targets for G-kinase in malaria
10:10 Olena Rudyk Oxidation of cGMP-dependent protein kinase Iα in the lung during chronic hypoxia mediates an endogenous adaptation to pulmonary hypertension
10:25-10:55 COFFEE BREAK
Session 7
Natriuretic peptides
Chairs:
Kazuwa Nakao, Kyoto
Sönke Behrends, Braunschweig
10:55 Amie Moyes,
London
C-type natriuretic peptide regulates cardiac structure & function
11:15 Stuart Bunting,
San Francisco
NEP resistant CNP for bone growth disorders
11:35 Michaela Kuhn,
Würzburg
GC-A regulates vascular permeability and leukocyte trafficking after myocardial ischaemia
11:55 Konstanze Michel
Würzburg
C-type natriuretic peptide: a friend of the heart
12:10-14:00
Poster Session 3
SNACK AND REFESHMENTS
Session 8
Phosphodiesterases
Chairs:
Harald Schmidt, Maastricht
Andreas Friebe, Würzburg
14:00 David Kass,
Baltimore
New insights into leveraging PKG signalling to treat diseased hearts
14:20 Manuela Zaccolo,
Oxford
PDE/cAMP regulation of cardiac hypertrophy
14:40 Rodolphe Fischmeister,
Paris
PDE2 regulation of cGMP/cAMP crosstalk in the myocardium
15:00 Michael Russwurm,
Bochum
Real-time measurements of cGMP in cardiac, neuronal and renal cells
15:20 Nadja Bork
Hamburg
Changes in cardiomyocyte cGMP dynamics during hypoxia/re-oxygenation
15:35-16:05 COFFEE BREAK
Session 9
Poster Presentation
Chairs:
Peter Sandner, Wuppertal
Annie Beuve, Newark
16:05–17:30 6 selected posters 5 minute rapid fire oral presentations of selected posters
17:30–18:00 ORAL & POSTER PRIZE COMMITTEE MEETINGS
19:00–22:30 AWARD DINNER & CEREMONY

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