cGMP: Generators, Effectors and
Therapeutic Implications
Pre-final Program (last updated: March 12, 2024)
All titles in italics are preliminary and will be updated in April or even earlier
Friday, June 28, 2024
| 13:00-13:55 | Registration & Welcome Reception | |
| 13:55 | Harald Schmidt, Maastricht |
Welcome to Lübeck |
| S1 | Session 1: Clinical Translation |
Chairs: Peter Sandner, Wuppertal Mark Gladwin, Maryland |
|
| S1-01 14:00 | Dominik Steubl, Ingelheim |
sGCa BI685509 in chronic kidney disease - results from a Phase 2 clinical trial |
| S1-02 14:20 | Karen Paraschin, Wuppertal |
The sGC Activator runcaciguat reduces albuminuria in patients with chronic kidney disease (CKD): Results from the phase 2 CONCORD study |
| S1-03 14:40 | Rafael De la Espriella, Valencia |
NOS recoupling with L-citrulline, folate, and vericiguat in a NOX5-positive subgroup of HFpEF patients: A Phase IIa proof-of-concept trial |
| S1-04 15:00 | Essam Metwally, Rahway |
Structural insights into selective small molecule activation of PKG1α |
| S2 | Session 2: cGMP in the Cardiovascular System |
Chairs: Friederike Cuello, Hamburg Robert Lukowski, Tübingen |
|
| S2-01 15:20 | Miriam Cortese-Krott, Düsseldorf |
The role of NO/sGC signalling in erythropoiesis |
| S2-02 15:40 | Amie Moyes, London |
CNP regulates cardiac and vascular function in sepsis |
| S2-03 16:00 | Marie-Ange Renault, Bordeaux |
sGC is a promising therapeutic target for the management of lower limb ischemia |
| S2-04 16:20 | N.N. |
t.b.a |
| 16:40-17:00 | COFFEE BREAK | |
| S3 | Session 3: cGMP in Cancer Biology (and Metabolism) |
Chairs: Franz Hofmann, München Michael Marletta, Berkeley |
|
| S3-01 17:00 | Donald P. McDonnell, Durham |
Manipulation of cancer cell intrinsic and extrinsic cGMP signaling as a therapeutic approach in cancer |
| S3-02 17:20 | Robert Feil, Tübingen |
NO/cGMP signaling in the tumor microenvironment |
| S3-03 17:40 | N.N. |
t.b.a. |
| 18:00–19:00 | SNACK AND REFRESHMENTS | |
| MML | Ferid Murad Memorial Lecture |
Chair: Sheila Collins, Nashville |
|
| MML-01 19:00-19:45 |
Alexander Pfeifer, Bonn |
Regulation of Metabolism by cGMP: Focus on adipose tissue and obesity |
| 19:45–22:00 | POSTER SESSION I | |
Saturday, June 29, 2024
| S4 | Session 4: NO-GC Structure, Modulators, Function |
Chairs: Miriam Cortese-Krott, Düsseldorf Andreas Friebe, Würzburg |
|
| S4-01 08:30 | N.N. |
t.b.a. |
| S4-02 08:50 | Michael Marletta, Berkley |
Molecular aspects of sGC activation and stimulator function |
| S4-03 09:10 | Jon O. Lundberg, Stockholm |
Is NO-ferroheme a signalling entity? |
| S4-04 09:30 | Mark Gladwin, Maryland |
NO-ferroheme regulates intravascular NO/cGMP via NO-GC |
| S4-05 09:50 | Thorsten Kessler, München |
cGMP in atherosclerosis: genetic and mechanistic insights |
| 10:10-10:40 | COFFEE BREAK | |
| S5 | Session 5: Emerging Fields |
Chairs: Peter Sandner, Wuppertal Robert Lukowski, Tübingen |
|
| S5-01 10:40 | N.N. |
t.b.a. |
| S5-02 10:55 | N.N. |
t.b.a. |
| S5-03 11:10 | N.N. |
t.b.a. |
| S5-04 11:25 | N.N. |
t.b.a. |
| 11:40–13:30 | SNACK AND REFRESHMENTS | |
| POSTER SESSION II | ||
| 13:30-17:00 | FREE TIME | |
| 17:00-17:15 | COFFEE BREAK | |
| S6 | Session 6: Crosstalk |
Chairs: Robert Feil, Tübingen Michaela Kuhn, Würzburg |
|
| S6-01 17:15 | John Pernow,
Stockholm |
Cardioprotective effects of erythrocytes mediated by soluble guanylate cyclase and release of cGMP |
| S6-02 17:35 | Viacheslav O. Nikolaev,
Hamburg |
Regulation of cardiac contractility and hypertrophy by cGMP nanodomains |
| S6-03 17:55 | Michael Russwurm, Potsdam |
NO-induced cGMP in the heart: Role of Phosphodiesterases in physiology and pathophysiology |
| S6-04 18:15 | N.N. |
t.b.a. |
| 18:35-20:15 | SNACK AND REFRESHMENTS | |
| POSTER SESSION IIIa | ||
| EL | Evening Lecture | Chair: Harald Schmidt, Maastricht |
|
| EL-01 20:15-21:00 |
Joseph Loscalzo,
Boston |
Network Approach to Drug Target Identification and Drug Combinations: Implications for cGMP-based Therapeutics |
| 21:00-22:00 | POSTER SESSION IIIb | |
Sunday, June 30, 2024
| S7 | Session 7: Non-canonical Signaling and Novel Aspects |
Chairs: Johannes-Peter Stasch, München Michael Russwurm, Potsdam |
||
| S7-01 08:50 | Jean-Pierre Saint-Jeannet, New York |
The functions of Npr3 during embryonic development | |
| S7-02 09:10 | Sheila Collins
Nashville |
Natriuretic Peptide Signaling – Some Old, Some New – and Roles in Adipose Biology | |
| S7-03 09:30 | N.N. |
t.b.a. | |
| 09:50-10:10 | COFFEE BREAK | ||
| S8 | Session 8: Natriuretic Peptides, their Receptors and beyond |
Chairs: Viacheslav O. Nikolaev, Hamburg Sheila Collins, Nashville |
||
| S8-01 10:10 | Valentina Cannone,
Parma |
MANP: A natriuretic peptide-based therapy for cardiometabolic diseases | |
| S8-02 10:30 | Michaela Kuhn, Würzburg |
Endothelial natriuretic peptide receptor-C: All clear? | |
| S8-03 10:50 | Susanne Kämmerer, Dresden |
cGMP-induced PDE2 stimulation as a novel antiarrhythmic strategy | |
| S8-04 11:10 | Eric Schneider,
San Fransico |
Development of a long acting C-natriuretic peptide suitable for QMo dosing | |
| S8-05 11:30 | N.N. |
t.b.a. | |
| 11:50-13:00 | SNACKS AND REFRESHMENTS | ||
| POSTER SESSION IV | |||
| S9 | Session 9: Technological Advances & New Applications |
Chairs: Harald Schmidt, Maastricht Susanne Kämmerer, Dresden |
||
| S9-01 14:50 | Jian Yang, New York |
Conformational landscape of cGMP activation of the human cone photoreceptor CNG channel | |
| S9-02 15:10 | Purnima Bhanot, New Jersey |
PfPKG inhibitors for malaria chemo prevention | |
| S9-03 15:30 | N.N. |
t.b.a. | |
| 15:50-16:20 | COFFEE BREAK | ||
| S10 | Session 10: Special session of the DGPT |
Chair: Roland Seifert, Hannover |
||
| S10-01 16:20 | Naunyn-Schmiedeberg Prize awarded by the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) | ||
| S11 | Session 11: Poster Presentations “Rapid Fire” |
Chairs: Miriam Cortese-Krott, Düsseldorf Adrian Hobbs, London |
||
| S11-01 16:40 | 3 to 5 selected posters | 5 minute rapid fire oral presentations of selected posters | |
| 17:15-18:00 | ORAL & POSTER PRIZE COMMITTEE MEETINGS | ||
| 18:45-23:00 | AWARD DINNER & CEREMONY | ||