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Lectures and Posters
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Saturday, June 14, 2003
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| 18:45 |
Harald Schmidt,
Giessen |
Welcome and Opening Remarks |
Honorary
Lecture |
Chair: Ferid Murad, Houston |
| 19:00 |
David Garbers,
Dallas |
The adversial relationship between growth factor and C-type natriuretic peptide signaling pathways |
20:00 | WELCOME RECEPTION, HOTEL RENAISSANCE |
Sunday, June 15, 2003
Session 1
NO/sGC
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Chair: Günter Schultz, Berlin |
| 8:00 | John
Garthwaite, London | Dynamics of NO/cGMP signaling in
the CNS |
| 8:30 | Michael
Marletta, Berkeley | Characterization of heme protein sensors provides a basis for functional differences such as ligand recognition |
| 9:00 | Doris Koesling, Bochum | News within NO/cGMP signaling |
9:30 - 10:00 | COFFEE BREAK |
Session 2
NO/sGC |
Chair: David Garbers, Dallas |
| 10:00 | Emil Martin, Houston | A constitutively active heme-deficient mutant of human soluble guanylyl cyclase: implications for the mechanisms of sGC activation | | 10:30 | Werner
Müller-Esterl,
Frankfurt | Identification of proteins associated with soluble guanylyl cyclase | | 11:00 | Pavel Nedvetsky, Giessen | Redox-dependent regulation of sGC protein and activity |
| 11:30 | Peter
Brouckaert, Gent | Target validation of sGC and its isoforms using conditional targeted mutagenesis in mice |
| 12:00 | Michaela
Kuhn, Münster | Conditional, cell-specific inactivation
of the
guanylylcyclase A receptor |
12:30- 14:00 | LUNCH and POSTER |
Session 3
Effector Systems |
Chair: Suzanne Lohmann, Würzburg |
| 14:00 | Joe Beavo,
Seattle | cGMP regulation of phosphodiesterases: structure and function |
| 14:30 | Sharron Francis,
Nashville | PDE5: new insights into regulation of enzyme functions |
| 15:00 | Sergei Rybalkin,
Seattle | Regulation of PDE5 activity by cGMP binding and phosphorylation |
| 15:15 | Georg Sager,
Tromso | Cellular efflux of cGMP - biology, pharmacology and clinical relevance |
15:30 - 16:00 | COFFEE BREAK |
Session 4
Effector Systems |
Chair: Thomas Lincoln, Birmingham |
| 16:00 | Hugo De Jonge,
Rotterdam | Cyclic GMP-dependent
protein kinase regulation of epithelial ion transporters |
| 16:30 | Xiaoping Du,
Chicago | Stimulatory role for PKG in platelet activation | | 17:00 | Ulrich
Walter,
Würzburg | Quantitative and functional analysis
of the NO/sGC/cGMP/VASP pathway in vitro and in vivo |
| 17:30 | Ingo
Weyand,
Jülich | Cyclic GMP elicits Ca2+ entry and thereby controls chemotaxis of sperm |
| 17:45 | Andreas
Ludwig,
München | Analysis of HCN2 and HCN4 knockout
mice |
| 18:15 | Pilar Monfort, Valencia | Sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in the CA1 area of hippocampus |
| 19:30 | ORGAN RECITAL
| THOMAS CHURCH |
| 20:30 | DINNER
| AUERBACH'S CELLAR |
Monday, June 16, 2003
Session 5
Physiology |
Chair: Matthias Schramm, Wuppertal |
| 8:00 | Thomas Lincoln,
Birmingham | Regulation of vascular smooth muscle cell gene expression and phenotype by cyclic GMP and cyclic GMP-dependent protein kinase |
| 8:30 | Franz Hofmann,
München | cGMP kinases as effectors of
cGMP
signaling and regulators of multiple functions |
| 9:00 | Wolfgang
Dostmann, Burlington | The spatial and temporal dynamics of intracellular cGMP in smooth muscle cells |
| 9:30 - 10:00 | COFFEE
BREAK |
Session 6
Physiology |
Chair: Rudi Busse, Frankfurt |
| 10:00 | Scott Waldman,
Philadelphia | Guanylyl cyclase C ligands confer resistance to colorectal cancer |
| 10:30 | Robert Feil,
München | cGMP kinases and atherosclerosis |
| 10:45 | Thomas
Münzel, Hamburg | Effects of oxidative stress on cGK activity and expression |
| 11:15 | Kai Wollert, Hannover | Nitric oxide as a negative regulator of cardiac myocyte hypertrophy - signaling pathways and novel downstream targets |
| 11:30 | Martin Feelisch, Shreveport | Tissue products of local nitrosative stress |
| 11:45 | David Morton, Portland | Atypical guanylyl cyclases: the invertebrate contribution |
| 12:00- 14:00 | LUNCH and POSTER |
Session 7
Pharmacology |
Chair: Ulrich Förstermann, Mainz |
| 14:00 | Bernd Mayer,
Graz | Metabolism of nitroglycerin by mitochondrial aldehyde dehydrogenase: In search for a link between nitrite formation and bioactivity |
| 14:15 | John Parker,
Toronto | Organic nitrates cause endothelial dysfunction |
| 14:45 | Ursula Schindler, Frankfurt | Pharmacology and biochemistry of novel compounds activating heme-oxidized soluble guanylyl cyclase |
| 15:15 | Johannes-Peter Stasch,
Wuppertal | NO- and heme-independent activation of soluble guanylyl cyclase: molecular basis and therapeutic implications |
| 15:45- 16:15 | COFFEE BREAK |
Session 8
Pharmacology |
Chair:
Werner Seeger, Giessen |
| 16:15 | Annie Beuve,Newark | Structure-function analysis of soluble guanylyl cyclase: unraveling mechanisms of regulation |
| 16:30 | Adrian
Hobbs, London | Novel non NO-dependent soluble guanylate
cyclase stimulators: pharmacological characterization and therapeutic
potential |
| 17:00 | John
Burnett, Rochester | Particulate and soluble guanylyl
cyclase stimulation in the treatment
of heart failure |
| 17:30 | John Wharton, London | PDE5 expression in human pulmonary hypertension and anti-proliferative effects of PDE5 inhibition in PASMC |
| 17:45 | Friedrich
Grimminger, Griessen | PDE5 expression in human pulmonary hypertension and anti-proliferative effects of PDE5 inhibition in PASMC |
| 19:30 | BISTRO
EVENING:
OLDTIMER MUSEUM "DA CAPO" |
Poster session
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Abbey,
Sarah E.,
Lincoln R. Potter | Lysophosphatidic
acid inhibits C-type natriuretic peptide activation of guanylyl
cyclase-B |
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Abbey,
Sarah E.,
Lincoln R. Potter | Vasopressin-dependent
inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B,
requires elevated intracellular calcium
concentrations |
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André,
Muriel,
Emanuela Felley-Bosco | NO-cGMP
signaling pathway in epithelial cells |
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Antl,
Melanie, Angela
Geiselhöringer, Franz Hofmann,
Jens Schlossmann | Phosphorylation
of the cGMP kinase substrate IRAG in platelets |
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Agulló,
Luis,
David Garcia-Dorado, Noelia
Escalona, Marisol Ruiz-Meana,
Javier Inserte, Jordi Soler-Soler | Effects
of ischemia on the cGMP-pathway in myocardial cells |
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Baltrons,
María Antonia,
Carlos E. Pedraza,
Michael T. Heneka,
Agustina García | Neuroinflammatory
agents down-regulate soluble guanylyl cyclase in astroglial
cells by nitric oxide-dependent and independent mechanisms |
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Bischoff,
Erwin,
Matthias Schramm,
Alexander Straub,
Achim Feurer,
Johannes-Peter Stasch | BAY
41-2272: a stimulator of soluble guanylyl cyclase induces
NO-dependent penile erection in vivo |
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Boerrigter,
Guido,
Lisa C. Costello-Boerrigter,
Gail J. Harty, Harald Lapp,
John C. Burnett, Jr | Cardiorenal
actions of the new heme-independent direct soluble guanylate
cyclase stimulator BAY 58-2667 in experimental congestive
heart failure |
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Bryan,
Paula,
Lincoln Potter | The
atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated
by distinct microcystin-sensitive and magnesium-dependent
protein phosphatases |
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Butt,
Elke, Christian Kaicher,
Stepan Gambaryan, Nina
Göttfert, Annette Galler,
Katrin Marcus and H. E. Meyer | Actin
binding of human LIM and SH3 Protein (LASP) is regulated
by cGMP-and cAMP-dependent protein kinase phosphorylation
on serine 146 |
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Cawley,
Sharon M.,
Carolyn Sawyer, Akira Honda,
Wolfgang R.G. Dostmann | Intracellular cGMP signalling in primary human smooth muscle cells |
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Connelly,
L., L.J. Ignarro ,
A.J. Hobbs | eNOS-derived
NO participates in lipopolysaccharide-stimulated iNOS expression
in murine macrophages via a cGMP-dependent
mechanism |
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Davies,
Shireen A., Kate E.
Broderick, Matthew R.
MacPherson, Laura Kean,
Nigel J. Pyne, Julian A.T.Dow | cGMP-specific
phosphodiesterase modulates renal function in Drosophila |
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Day,
Jonathan, Miles Houslay,
Shireen Davies | Cloning
and characterisation of a novel cGMP-specific phosphodiesterase
from Drosophila
melanogaster |
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De
Vente, Jan, Marjanne
Markerink-van Ittersum,
Wilma van Staveren,
Harry Steinbusch | NO-dependent
and NO-independent stimulation of soluble guanylyl cyclase
in the rat frontal cortex: localization and characterization. |
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Falcone,
S., C. De Palma,
C. Perrotta, R. Barsacchi,
S. Bulotta, O. Cantoni,
P. Sestili, S. Moncada,
N. Borgese, E. Clementi | The
cross-talk between nitric oxide and sphingomyelinases regulates
apoptosis induction by tumour necrosis factor |
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Faro,
Renato, Marcos Zanfolin,
Eugênio Gonçalves de Araújo,
Ana Maria Aparecida Guaraldo,
Edson Antunes, Gilberto De Nucci | Protective
effect of BAY 41-2272 (sGC stimulator) on hypertension and
heart hypertrophy induced by chronic L-NAME treatment in
rats |
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Feil,
S., R. Feil, J. Hartmann,
C. Luo, W. Wolfsgruber,
K. Schilling, J.J. Barski,
M. Meyer, A. Konnerth,
C.I. De Zeeuw,
F. Hofmann | Impairment
of cerebellar LTD and learning by Purkinje cell-specific
ablation of cGMP-dependent protein kinase |
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| Foley,
Kevin F., Sharon Cawley, Wolfgang Dostmann | Monitoring
cGMP in Neuronal Cells Using FRET |
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Foresti,
Roberta, Jehad Hammad,
Tony R. Johnson, Colin
J Green, Brian E.
Mann and Roberto Motterlini | Vasorelaxant
properties of corm-3, a new water-soluble carbon monoxide-releasing
molecule |
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Friebe,
Andreas,
Florian Müllershausen,
Michael Russwurm,
Doris Koesling | Functional
reconstitution of NO/cGMP signalling: Implications for NO
tolerance |
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Gambaryan,
Stepan,
Elke Butt, Margarita Glazova,
Albert
Smolenski, Ulrich Walter | cGMP
dependent protein kinase type II regulates basal level of
aldosterone release from zona glomerulosa cells without activating
StAR gene expression |
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| Hobbs,
Adrian J. | Anti-inflammatory
activity of soluble guanylate cyclase: cyclic GMP-dependent
down-regulation of P-selectin expression and leukocyte recruitment |
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Hofer,
Alexandra, Alexander
Kollau, Wing Ming Keung,
Kurt Schmidt, Bernd Mayer | Metabolism
of nitroglycerin by rat liver mitochondria and purified mitochondrial
aldehyde dehydrogenase |
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Ji,
Yanbin, Diane J. Anderson,
Brian M. Bennett | Endothelial
cell apoptosis as a mechanism of endothelial dysfunction
in nitrate tolerance |
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Kilic,
Ana, Frank Begrow,
Michaela Kuhn | Altered
Ca2+-handling in cardiomyocytes from guanylyl cyclase-A deficient
mice |
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| Klimenko,
Oxana | The
influence of nitric oxide on some blood hemostatic indices |
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| Klimenko,
Oxana, A. Solpov | The
influence of nitric oxide on functional activity of immune
system |
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Kobsar,
Anna, Sonja Heeg,
Katharina Krohne, Birgitta Schinke,
Ulrich Walter, Suzanne
M.Lohmann, Martin Eigenthaler | cGMP
regulates hematopoietic stem cell proliferation and differentiation |
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Kollau,
Alexander, Alexandra
Hofer, Wing Ming Keung,
Rudolf Russwurm,
Doris Koesling, Kurt Schmidt,
Bernd Mayer | Bioactivation
of nitroglycerin: Activation of purified soluble guanylyl
cyclase in the presence of rat liver mitochondria |
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Kuethe,
Andrea, Christian
G. Stief, Urs Albrecht | Does
a novel phosphodiesterase type 11A4 mutation influence human
benign prostate hyperplasia? |
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Lyamina,
Nadegda,
Valeri Senchihin,
Svetlana Lyamina | The
Tie between Functional Activity of Trombocytes and NO Production
in Arterial Hypertension Patient |
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Madhani,
Melanie,
Raymond MacAllister,
Adrian Hobbs | Interactions
between soluble guanylate cyclase and natriuretic peptide
receptor-linked particulate guanylate cyclases in the mammalian
vasculature |
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Mo,
Elaine, Hemisha Amin,
John Garthwaite | Dynamics
of a NO-cGMP phosphorylation pathway |
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Müllershausen,
Florian,
Martin Hennenberg, Andreas
Friebe, Doris Koesling | Desensitisation
of NO/cGMP signalling in platelets and smooth muscle |
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Obih,
P., J. Soblosky, C.
Rich, P. Rich, F. Wang,
B. Potter | Ft02B
cells-a novel rat hepatoma cell line for the study of ethanol
metabolism and nitric oxide |
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Oster,
Henrik, Claudia Werner,
Maria Chiara Magnone,
Helmut Mayser, Robert Feil,
Mathias W. Seeliger,
Franz Hofmann, Urs Albrecht | cGMP-dependent
protein kinase II modulates mPer1 and mPer2 gene induction
and influences phase shifts of the circadian clock |
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Parnova,
Rimma, Ekaterina Fock,
Elena Lavrova, Vera Bachteeva,
Elena Chernigovskaya | Different
role of cGMP generated by soluble and particulate guanylyl
cyclase in regulation of osmotic water permeability in the
frog urinary bladder |
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Peters,
Harm, Ying Rui Wang,
Sebastian Martini, Matthias
Rückert, Stephanie Krämer,
Hans-H. Neumayer | Impaired
NO signal transduction is linked to transforming growth factor
(TGF)-ß overexpression in anti-thy1 glomerulonephritis |
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Potthast,
Regine, Sarah
E. Abbey, Michaela Kuhn,
Lincoln R. Potter | Rapid
and Reversible Inhibition of the C-type Natriuretic Peptide
Receptor (NPR-B/GC-B) by Hyperosmolarity |
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Radenkovic,
Miroslav,
Srdan Pesic,
Leposava Grbovic | The
role of endothelium functional integrity in isolated human
umbilical artery response to serotonin |
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Rodrigo,
Regina,
Nicolas Chatauret,
Roger Butterworth,
Vicente Felipo | Content
and modulation of soluble guanylate cyclase are altered in
brain of cirrhotic patients: Differential alterations in
cerebellum and cortex |
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Sabrane,
Karim, Stepan
Gambaryan, Rita Holtwick,
Melanie Voß, Michaela Kuhn | Reciprocal
regulation of cGMP-mediated vasorelaxation by soluble and
particulate guanylyl cyclases: lessons from SMC GC-A KO mice |
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| Sandner,
Peter, Helga Vitzthum | Expression
and regulation of CGMP degrading Phosphodiesterases in the
kidney of DAHL rats |
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Sausbier,
Matthias, Hong Zhao,
Rudolf Schubert, Susi Feil, Iancu Bucurenciu, Xia-Bo Zhou,
Kyrill Essin, Robert Feil,
Michael Korth, Mike Gollasch,
Franz Hofmann, Claudia Arntz,
Peter Ruth | Genetic
ablation of the BK channel in mice: augmentation of tone,
attenuation of NO/cGMP-mediated dilation in small resistance
vessel-sized arteries and hypertension |
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Sausbier,
Matthias, Hong Zhao,
Rudolf Schubert, Susi Feil,
Iancu Bucurenciu, Xia-Bo Zhou,
Kyrill Essin, Robert Feil,
Michael Korth, Mike Gollasch,
Franz Hofmann, Claudia Arntz,
Peter Ruth | Augmentation
of tone, attenuation of NO/cGMP-mediated dilation and hypertension
in small resistance vessel-sized arteries of BK channel deficient
mice |
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Schmidt,
Hannes, Matthias
Werner, Paul A. Heppenstall,
Mechthild Henning, Margret,
Moré, Susanne Kühbandner,
Gary R. Lewin, Franz Hofmann
Robert Feil, Fritz G. Rathjen | cGMP-mediated
signalling via cGKI is required for the guidance and connectivity
of sensory axons |
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Schmidt,
Peter, Matthias Schramm,
Henning Schröder, Johannes-Peter
Stasch | Mechanisms
of nitric oxide independent activation of soluble guanylyl
cyclase |
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Schmidt,
Peter, Matthias Schramm,
Henning Schröder, Johannes-Peter
Stasch | Potentiating effect of ODQ on the BAY 58-2667-induced sGC activation |
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Schultess,
Jan, Oliver Danielewski,
Albert Smolenski | cGMP-dependent
protein kinase I inhibits agonist induced Rap1 activation
in human platelets |
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Sekharan,
Monica R.,
Won J. Rhee, Joseph A. Beavo,
Rachel E. Klevit | PDE5 Site A: A structural analysis of cGMP binding |
Sharina,
Iraida G., Emil Martin,
Anthony Thomas, Karen L. Davis,
Ferid
Murad | CBF
regulates expression of the ß1sGC gene
in the BE2 human neuroblastoma cells |
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Sindic,
Aleksandra, Jochen R.
Hirsch, Ana Velic, Candan Basoglu,
Michaela Kuhn, Eberhard Schlatter | Guanylate
cyclase G and GPR14 are receptors for guanylin peptides in
principal cells of mouse and human CCD |
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Van
Staveren, Wilma C.G.,
Harry W.M. Steinbusch,
Marjanne Markerink-van
Ittersum,
Sönke Behrends, Jan de Vente | Species
differences in localization of cGMP-producing and NO-responsive
elements in the mouse and rat hippocampus |
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Weeks
II, James L., Mitsi A. Blount, Alfreda Beasley, Jun Kotera,
Yew S.J. Ho, Karl P. Kuhn,
Layla F. Saidi, James H. Hurley,
Sharron H.
Francis, Jackie D. Corbin | New
features of PDE5 as revealed by a potent catalytic-site specific
radioligand |
| Werner, Claudia, Jens Schlossmann,
M. Schiemann, K.B. Pryzwansky,
Franz Hofmann | Cyclic GMP kinase I is involved in the regulation of cytosolic calcium
transients in murine neutrophils | |
Werner,
Matthias,
Angela Geiselhöringer,
Susanne Feil, Robert Feil,
Jens Schlossmann, Franz Hofmann | Gastrointestinal
dysfunction mediated by an IRAG mutation in mice |
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Werner,
Claudia,
Jens Schlossmann, M. Schiemann,
K.B. Pryzwansky,
Franz Hofmann | Cyclic GMP kinase I is involved in the regulation of cytosolic calcium transients in murine neutrophils |
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Witwicka,
Hanna, Marcin Kobialka,
Jakub Siednienko, Ewa Kurowska, Wojciech
A. Gorczyca | Cyclic
GMP-regulated PDEs appear to be the main effectors for cyclic
GMP in rat peritoneal macrophages |
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Wu,
Albert, Xiao-Bo Tang,
Joseph Beavo | Molecular
mechanism of cyclic nucleotide binding to the GAF domains
of Phosphodiesterase 2A |
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Wunder,
Frank, Cristina Alonso-
Alija, Emanuel Lohrmann,
Jörg Hüser, Johannes-Peter Stasch | An
automated aequorin luminescence-based functional assay used
to identify BAY 58-2667, a new NO-independent soluble guanylate
cyclase activator |
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Wykes,
Victoria, Barry Gibb,
John Garthwaite | Kinetic
characteristics of the guanylyl cyclase-coupled receptor |
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Zhou,
Zongmin, Charis Roussos,
Andreas Papapetropoulos | Identification
of the domains required for soluble guanylate cyclase dimerization |
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Zimmermann,
Kirstin, Nils Opitz,
Simone Matt, Stefanie Oess,
Werner Müller-Esterl | NOSTRIN
- a molecular clamp securing the eNOS-caveolin complex |
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Zoraghi,
Roya, Jackie D. Corbin,
Sharron H. Francis | Identification
of structural and functional features in human PDE5 regulatory
domain that provide for allosteric cGMP binding and for dimerization |
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