|
| |
Print Version
Lectures and Posters
|
Friday, June 15, 2007
|
| 14:00 |
Franz Hofmann,
München |
Welcome |
| Plenary Talk |
Chair: Franz Hofmann, München
|
| 14:10 |
Joachim Schultz,
Tübingen |
Characterization of tandem GAF domains of PDEs |
Session 1
Cardiopulmonary Pharmacology
|
Chair: John Burnett, Rochester
Johannes-Peter Stasch, Wuppertal |
| 14:40 |
Oleg Evgenov,
Boston |
Therapeutic potential of soluble guanylate cyclase agonists in pulmonary hypertension |
| 15:00 |
Ralph Schermuly,
Gießen |
sGC stimulators in experimental pulmonary hypertension |
| 15:20
|
Martin van Eickels,
Frankfurt |
Role of sGC activator HMR 1766 in cardiovascular disease |
| 15:40 |
Barbara Kemp-Harper,
Melbourne |
Oxidised sGC: a novel therapeutic target in the vasculature |
| 16:00 |
David Kass,
Baltimore
|
Molecular modulators of cardiac stress targeted by PDE5 inhibition |
| 16:20 |
Adrian Hobbs,
London
|
Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension |
| |
| 16:40 – 17:10 |
COFFEE BREAK |
| |
Session 2
Clinical breakthroughs: Heart & Lung |
Chair: Warren Zapol, Boston
John Parker, Toronto |
| 17:10 |
Ardeschir Ghofrani,
Gießen |
Clinical results with the sGC stimulator BAY 63-2521 in patients with pulmonary hypertension |
| 17:30 |
Harald Lapp,
Erfurt
|
Clinical results with the sGC activator BAY 58-2667 in patients with acute decompensated heart failure |
| 17:50 |
Mark Semigran,
Boston
|
The emerging role of PDE5 inhibition in heart failure |
| 18:10 |
Veselin Mitrovic,
Bad Nauheim
|
Clinical trials with urodilation in patients with acute decompensated heart failure |
| 18:30
|
Tommaso Gori,
Siena
|
The NO-cGMP axis in endothelial ischemia and ischemic preconditioning |
| 18:50 |
Vicente Felipo,
Valencia |
Restoration of learning in hepatic encephalopathy by pharmacological manipulation of cGMP levels in brain |
| |
19:10-20:00
Session 3
Guided Posters |
SNACK & REFESHMENTS,
WINE & BEER |
| Molecular Mechanisms |
Chair: Günter Schultz, Berlin
|
| cGMP assays and reporters |
Chair: Rodolphe Fischmeister, Paris
|
| Platelets/VSMC |
Chair: Jens Schlossmann, Regensburg
|
| |
| Evening Lecture |
Chair: Günter Schultz, Berlin
|
| 20:00 |
John Burnett,
Rochester |
Modulating cGMP in heart failure |
| |
|
|
| 21:00-22:00 |
WINE & BEER CONTINUED AT THE POSTERS |
Saturday, June 16, 2007 |
Session 4
Genetic Models |
Chair: Ferid Murad, Houston
Renate Pilz, San Diego |
| 08:00 |
Franz Hofmann,
München
|
Analysis of mice with genetic modifications of PKG I |
| 08:20 |
Peter Brouckaert,
Ghent |
Transgenic mice with a NO-insensitive soluble guanylate cyclase |
| 08:40 |
Michaela Kuhn,
Würzburg |
Guanylyl cyclase-A mediated endothelial actions of natriuretic peptides are critically involved in postischemic reperfusion |
| 09:00 |
Ruey-Bing Yang,
Taiwan |
Receptor guanylyl cyclase-G-deficient mice are protected against renal ischemia-reperfusion injury by preventing apoptosis and inflammation
|
| 09:20 |
Robert Feil,
Tübingen |
New mouse models for the analysis of cGMP signalling |
| 09:40 |
John Garthwaite,
London |
A mouse (and chips) model for NO-activated guanylyl cyclase |
| 10:00-10:30 |
COFFEE BREAK |
| |
Session 5
Reporters and cGMP Detection |
Chair: Harald Schmidt, Melbourne
John Catravas, Georgia |
| 10:30 |
Martin Lohse,
Würzburg
|
Rapid monitoring of intracellular cGMP |
| 10:50 |
Lydia Nausch,
Burlington
|
FlincGs: novel, non-FRET cGMP biosensors with nanomolar sensitivity for NO-induced signaling |
| 11:10 |
Rodolphe Fischmeister,
Paris |
cGMP compartments in cardiac myocytes |
| 11:30 |
Michael Russwurm,
Bochum
|
Design and characterization of FRET-based cGMP indicators |
| 11:50 |
Elke Butt,
Würzburg
|
Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities |
| 12:10 |
Robert Blanton,
Boston
|
In vivo evidence that cyclic GMP-dependent protein kinase G type I α mediates an anti-hypertrophic pathway in the heart |
| |
|
| |
|
12:30-13:30
Session 6
Guided Poster Session |
SNACKS AND REFRESHMENTS AT THE POSTERS |
| Heart/Lung |
Chair: Mark Semigran, Boston
|
| Cardiovascular/ Urology |
Chair: Gilberto De Nucci, Sao Paulo
|
| CNS |
Chair: Vicente Felipo, Valencia
|
| |
| 13:30-17:00 |
DRESDEN VISIT
Guided visit of the Semper Opera
followed by a guided walking tour of the historic Dresden. |
| |
Ferid Murad Lecture |
Chair: Ferid Murad, Houston |
| 18:00
|
Michael Marletta,
Berkeley |
A life-time achievement lecture in cGMP: “Molecular steps in sGC activation” |
Session 7
PDEs |
Chair: Doris Koesling, Bochum
Jackie Corbin, Tennessee |
| 18:45 |
Delphine Behr-Roussel,
Gif-sur-Yvette |
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses endothelial dysfunction and oxidative stress associated with the metabolic syndrome |
| 19:05 |
Sergei Rybalkin,
Seattle
|
Phosphorylation of cAMP hydrolyzing PDE (PDE3A) by cGMP-dependent protein kinase (PKG) in human platelets |
| 19:25 |
Jackie Corbin,
Nashville
|
Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle |
| 19:45 |
Krassimira Ivanova,
Köln
|
Melanocytes: interface of cell biology and pathobiology with a focus on nitric oxide and cGMP signaling |
Sunday, June 17, 2007 |
Session 8
Guanylyl Cyclases |
Chair:
Michael Marletta, Berkeley
Andreas Papapetropoulos, Patras |
Plenary Talk
08:00
|
Kazuwa Nakao,
Kyoto
|
Natriuretic peptides: from bench to bedside |
| 08:30 |
Michael Wolin,
New York |
Influence of heme metabolism and redox regulation of sGC in the control of vascular function |
| 08:50 |
Werner Müller-Esterl,
Frankfurt |
Oxidative stress induces CHIP-mediated ubiquitination and roteasomal degradation of soluble guanylyl cyclase |
| 09:10 |
John Catravas,
Georgia |
Hsp90 and sGC-mediated vasorelaxation |
| 09:30 |
Christiane Rothkegel,
Wuppertal |
Insights into activation and dimerization of sGC |
| 09:50 |
Focco van den Akker,
Cleveland |
Structural insights into sGC |
| 10:10 |
Emil Martin,
Houston |
Dynamic ligand exchange as mechanism for sGC selectivity, NO activation and its reversal |
| 10:30-11:00 |
COFFEE BREAK |
| |
Session 9
cGMP Signalling & Effectors |
Chair: Franz Hofmann, München
Werner Müller-Esterl, Frankfurt |
| 11:00 |
Xin-Yun Huang,
New York
|
A new Rac-cGMP signaling pathway |
| 11:20 |
Michael Mendelsohn,
Boston
|
PKG in vascular development and disease |
| 11:40 |
Robert Lukowski,
München
|
Vascular remodelling in the absence and presence of cGKI |
| 12:00 |
Andreas Papapetropoulos,
Patras |
sGC activation promotes angiogenesis |
| 12:20
|
Paula Pifarré,
Bellaterra |
NO-sensitive guanylyl cyclase β1 subunit interacts with chromosomes during mitosis: novel role in the regulation of chromatin condensation |
| |
12:40-13:40
Session 10
Guided Poster Session |
SNACKS AND REFRESHMENTS AT THE POSTERS |
| sGC/PKG |
Chair: Michaela Kuhn, Würzburg
|
| Endothelium |
Chair: Elke Butt, Würzburg
|
| Others |
Chair: Annie Beuve, Newark
|
| |
Session 11
Functions of cGMP: CNS |
Chair: Thomas Kleppisch, München
Frank Menniti, Groton |
| 13:40 |
Doris Koesling,
Bochum |
Functional roles of isoforms of NO-sensitive guanylyl cyclase |
| 14:00 |
Boris Hogema,
Rotterdam |
cGK II regulation of NHE3 and CFTR: role of PDZ domain proteins |
| 14:20 |
Marla Sokolowski,
Toronto |
cGMP kinase and food-related behaviours |
| 14:40 |
Agne Stonkute,
Berlin |
cGMP signaling and bifurcation of sensory axons at the dorsal root entry zone of the spinal cord |
| 15:00 |
Frank Menniti,
Groton |
Regulation of cGMP by phosphodiesterases (PDEs) in the central nervous system |
| |
Session 12
Fuctions of cGMP: Platelets |
Chair: Ulrich Walter, Würzburg
Robert Feil, Tübingen |
| 15:20 |
Jens Schlossmann,
Regensburg |
Signaling of NO/cGMP via IRAG |
| 15:40 |
Stephan Gambaryan,
Würzburg |
NO/cGMP/PKG pathway in platelets: stimulatory or inhibitory? |
| 16:00 |
Steffen Massberg,
Boston |
Increased aggregation of platelets lacking cGKI/PKG |
| 16:20-16:50 |
COFFEE BREAK |
| |
Session 13
Poster Prize Session |
Chair: Barbara Kemp-Harper, Melbourne
Adrian Hobbs, London |
| 16:50-17:20 |
NN |
Each candidate may talk for 3 min and show up to 3 slides or overheads and allow for 2 min question time |
| |
| Session 14
Committee Meetings |
|
| 17:20-17:45 |
Poster Prize Committee |
Selected out of poster presentations |
| 17:20-17:45 |
Young Investigator Award |
Selected out of all oral presentations |
| 17:20-18:00 |
Nomenclature Committee |
Chair: John Garthwaite, London |
| |
| 19:00 |
COCKTAIL AND DINNER at Ball- and Brauhaus Watzke
Award Ceremony
FAREWELL PARTY
|
| |
Poster Session
|
|
- Silvana Andric, Natasa Stojkov, Marija Janjic, Stanko Stojilkovic, Tatjana Kostic
cGMP signaling pathway is involved in Leyding cell stress response
- Reshma S Baliga, Lan Zhao, Martin R Wilkins, Raymond J MacAllister, Adrian J Hobbs
Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDEInhibitors: a novel combination therapy for pulmonary hypertension?
- María Antonia Baltrons, Paula Pifarré, María Teresa Berciano, Miguel Lafarga, Agustina García
LPS-induced down-regulation of NO-sensitive guanylyl cyclase in astrocytes occurs by proteasomal degradation in nuclear bodies
- Fernando R Báu, Cleber E Teixeira, Gilberto De Nucci, Edson Antunes
Relaxant effect of BAY 41-2272 in the rabbit isolated detrusor smooth muscle (DSM): involvement of cGMP-independent mechanisms
- Delphine Behr-Roussel, Alexandra Oudot, Sandrine Compagnie, Diana Gorny, Olivier Le Coz, Jaques Bernabé, Chris Wayman, Laurent Alexandre, Francois Giuliano
Daily treatment with sildenafil, an inhibitor of cGMP-dependent phosphodiesterase, normalizes the exaggerated hemodynamic response to norepinephrine in fructose-fed rats
- Brian Bennett, James Reynolds, Greg Thatcher
Selective activation of hippocampal guanylyl cyclase by a novel NO mimetic nitrate ester
- Matteo Beretta, Alexander Kollau, Michael Russwurm, Doris Koesling, Wing Ming Keung, Kurt Schmidt, Bernd Mayer
Activation of soluble guanylate cyclase in the presence of purified human aldehyde dehydrogenases
- Dominik Bernhard, Franz Hofmann, Jens Schlossmann
Relaxation of vascular smooth muscle by the cGMP-kinase substrate IRAG
- Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Harald Lapp, Johannes-Peter Stasch, John C Burnett, Jr
Targeting heme-oxidized soluble guanylate cyclase with BAY 58-2667 in experimental heart failure
- Liliana Castro & Rodolphe Fischmeister
Opposite effects of cGMP-dependent protein kinase on cGMP production by soluble andparticular guanylyl cyclase in adult ventricular myocytes
- Mário A Claudino, Juliana S Baracat, Enilton A Camargo, Fernanda BM Priviero, Cleber E Teixeira, Gilberto de Nucci, Angelina Zanesco, Edson Antunes
Run training ameliorates the established erectile dysfunction in rats under long-term nitric oxide (NO) blockade
- Lisa C Costello-Boerrigter, Guido Boerrigter, Gail J Harty,
John C Burnett, Jr
Coadministration of B-Type natriuretic peptide and the Vasopressin-2 receptorantagonist tolvaptan: a novel physiologic strategy to enhance water and sodiumexcretion without adversely affecting renal or neurohumoral function in experimentalcongestive heart failure
- Gilberto De Nucci, Raquel Lorenzetti, Cristina E Okuyama, Juliana S Baracat, José L Donato, Edson Antunes, Cleber E Teixeira
Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum
- Matthias M Desch, Katja Sig, Beate Spiessberger, Dominik Bernhard, Angela Jochim, Jörg W Wegener, Franz Hofmann, Jens Schlossmann
Analysis of smooth muscle function in IRAG knockout mice
- Ingeborg Dhaese, Gwen Vanneste, Robrecht Thoonen, Peter Brouckaert, Romain Lefebvre
NO-induced motility effects in gastric fundus and pylorus of sGCß1his105phe mutantmice
- Jeffrey M Dodd-o, Maria L Hristopoulos, Jolanta Gutkowska, S Mukaddam-Daher, K Kibler, A Gonzalez, David B Pearse
Reperfusion lung injury is attenuated by natriuretic peptide receptor antagonist in in- vivo mouse model
- Elisabeth Eder, Martin van Eickels, Stefan Frantz, Katharina Völker, Hideo A Baba, Michaela Kuhn
Chronic inhibition of cyclic GMP phosphodiesterase 5A may promote pressure overload-induced chamber dilatation in mice
- Vicente Felipo, Blanca Piedrafita, Amparo Urios, Miguel A. Serra, A. del Olmo, José M Rodrigo, Carmina Montoliu
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients
- Haroldo A Flores Toque, Fernanda BM Priviero, Cleber E Teixeira, Edson Antunes, Gilberto de Nucci
Effect of new sildenafil analogues in the rabbit isolated aorta
- Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Georg Wensing
BAY 63-2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile and decreases peripheral vascular resistance in healthy male volunteers
- Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Georg Wensing
BAY 58-2667, a soluble guanylate cyclase activator, has a favourable safety profile and reduces peripheral vascular resistance in healthy male volunteers
- Andreas Friebe, Dieter Groneberg, Peter König, Doris Koesling
Physiological and pathological effects of complete sGC deletion
- Angeles Garcia-Pascual, Maria Sancho, Gonzalo Costa, Domingo Triguero
Interstitial cells of Cajal in the urethra as effectors of the nitric oxide action through the cyclic GMP pathway
- Dieter Groneberg, Doris Koesling, Andreas Friebe
Lack of NO-mediated NANC relaxation in mice deficient in NO-sensitive guanylyl cyclase
- Michael G Hahn, Cristina Alonso-Alija, Friederike Stoll, Markus Heil, Joachim Mittendorf, Karl-Heinz Schlemmer, Frank Wunder, Johannes-Peter Stasch
Design and synthesis of the first NO- and haem-independent sGC activator
BAY 58-2667 for the treatment of acute decompensated heart failure
- Michael Hartmann, Juliane Schröter, Viacheslav O Nikolaev, Albert Sickmann, Ruey-Bing Yang, Michaela Kuhn
Characterization of an epitope-tagged guanylyl cyclase-A receptor
- Stefan Heitmeier, Ute Schüssler, Wolfgang Schröter, Nils Burkhardt
A luminescence based biochemical assay for soluble guanylyl cyclase
- Michael Hoffmann, Uwe Thuss
Cardiovascular effects of the soluble guanylyl cyclase activator
BAY 58-2667 in anesthetized dogs
- Bernd Hohenstein, Christoph Daniel, Sandra Wittmann, Andrea Braun, Johannes-Peter Stasch, Christian Hugo
Increased mesangial cGMP levels prevent mesangial cell proliferation and matrix expansion in experimental glomerulonephritis
- Brenda K Huntley, John C Burnett, Jr.
Integrin receptor subtype antagonism augments BNP-Mediated cGMP generation in cultured human cardiac fibroblasts: evidence for particulate guanylate cyclase receptor and integrin receptor cross-talk
- Jennifer C Irvine, Barbara K Kemp-Harper, Robert E Widdop
The nitroxyl anion (HNO) donor, Angeli's salt, does not develop tolerance in vivo
- Jacques F Kameni-Tcheudji, Thérčse Keravis, Alain Le Bec, Luc Lebeau, Jean-Marie Strub, Alain van Dorsselaer, Claire Lugnier
Vascular smooth muscle PDE5 is much more sensitive to N-alkylated zaprinast than platelet PDE5
- Lida Kimmel, Wendy Adamowicz, Mary Collins, Robin Kleiman
Inhibitors of cAMP and cGMP phosphodiesterases enhance neurite outgrowth from cultured cortical neurons in a PKG dependent manner
- Tatjana Kostic, Marija Janjic, Natasa Stojkov, Stanko Stojilkovic, Silvana Andric
cGMP-Protein kinase G signaling pathway is involved in stimulation of Leydig cell steroidogenesis
- Thomas Krieg, Ole Maas, Ulrike Donat, Stephan B Felix
Vardenafil limits infarction at reperfusion in isolated rat hearts dependent on guanyly cyclase and PKG
- Lars S Kruse, Morten Mřller, Maiken Tibćk, Steen Gammeltoft, Jes Olesen, Christina Kruuse
DE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system: role in pathogenesis of migraine?
- Candace YW Lee, Guido Boerrigter, Gail J Harty, John C Burnett, Jr
Cardiorenal actions of a novel chimeric natriuretic peptide, CD-NP, as compared to
C-type natriuretic peptide, in the normal dog
- Candace YW Lee, Guido Boerrigter, Gail J Harty, John C Burnett, Jr.
Pharmacokinetic and pharmacodynamic study of a novel chimeric natriuretic peptide, CD-NP, in the normal dog
- Sivakkanan Loganathan, Tamás Radovits, Iwan R. Wirotanseng, Gábor Veres, Siegfried Hagl, Gábor Szabó
Effects of vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model
- Emil Martin, Elena Bogatenkova, Ka Bian, Marie-Francoise Doursout
Fresh look on old substances - new class of NO-independent regulators of soluble guanylyl cyclase activiy and function
- Fabiola Mónica, Gilberto de Nucci, Alice Bricola, Angelina Zanesco, Catarina Porto, Fernando Abdalla, Leandro Freitas, Maria Aparecida Teixeira, Edson Antunes
Supersensitivity of muscarinic receptors in rat isolated detrusor smooth muscle (DSM) after chronic nitric oxide inhibition
- Michael Nesheim, John Samis, John Walker, Timothy Fischer, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Lev Becker, Marlys Koschinsky, Richard Wenstone, Colin Downey, Cheng Hock Toh
The formation of a Ca2+-dependent complex of C-reactive protein and very low densitylipoprotein causes the biphasic transmittance waveform
- Viacheslav O Nikolaev, Sabine Herget, Martin J Lohse
FRET-based method for rapid screening of PDE-inhibitors in living cells
- Catherine M Panayiotou, Adrian J Hobbs
NPR-A gene deletion reverses vascular dysfunction associated with sepsis
- Andreas Papapetropoulos, Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, Charis Roussos, David Fulton, Annie Beuve
Protein kinase G phosphorylates soluble guanylyl cyclase and inhibits its activity
- Cindy Paul, Pascal Weinmeister, Robert Fei, Franz Hofmann, Thomas Kleppisch
cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala
- Anastasia Pyriochou, Zongmin Zhou, Andreas Papapetropoulos
cGMP-dependent and -independent angiogenesis-related properties of nitric oxide
- Peter Sandner, Hanna Tinel, Beatrix Stelte-Ludwig, Erwin Bischoff, Joachim Huetter
The use of PDE5 inhibitors in the treatment of benign prostate hyperplasia and lower urinary tract symptoms: preclinical evidences
- Nazish Sayed, David Kim, Walter N Durán, Annie Beuve
S-nitrosylation of soluble guanylyl cyclase: a novel mechanism of nitrate tolerance?
- Nazish Sayed, Padmamalini Baskaran, Focco van den Akker, Annie Beuve
Desensitization of soluble guanylyl cyclase, the NO-receptor, by S-nitrosylation
- EP Schmidt, AJ Gonzales, LE Servinsky, JM Dodd-o, David B Pearse
Increased ventilatory lung stretch alters the effect of soluble guanylyl cyclase-derived cGMP on endothelial barrier function in isolated mouse lungs
- Achim Schmidtko, Wei Gao, Matthias Sausbier, Inga Grundei, Ellen Niederberger, Klaus Scholich, Andrea Huber, Hans-Dieter Allescher, Franz Hofmann, Peter Ruth, Gerd Geisslinger
Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception
- Barbara Schreier, Birgit Gaßner, Katharina Völker, Stepan Gambaryan Michaela Kuhn
ANP changes microvascular endothelial barrier function in vivo
- Raphaela Schwappacher, Joerg Weiske, Verena Ezerski, Sylke Hassel, Otmar Huber, Petra Knaus
Cyclic GMP-dependent kinase I promotes BMP signaling
- Iraida G Sharina, Emil Martin, Elena P Bogatenkova, VG Sharin, Ferid Murad
New human alpha1 soluble guanylyl cyclase splice variants as potential regulators of sGC activity
- Albert Smolenski, Meike Hoffmeister, Pavel Riha, Olga Neumüller, Oliver Danielewski, Jan Schultess
cGMP-dependent protein kinase regulates Rap1 signaling in platelets
- Gábor Szabó, Gábor Veres, Tamás Radovits, Christiane Miesel-Gröschel, Matthias Karck
Vardenafil improves myocardial and endothelial function after cardiopulmonary bypass
- Cleber E Teixeira, Fernanda BM Priviero, R Clinton Webb
Effects of BAY 41-2272 on smooth muscle tone, soluble guanylyl cyclase activity and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal and endothelial NOS null mice
- Ranji Thomas, Jane Fisher, Richard Heppell, Nigel Brayshaw , Sarah Cluck, Claire Gilbert, Ghazwan Butrous, Kayvan Kamalvand
The effects of chronic sildenafil therapy in patients with stable systolic heart failure
- Robrecht Thoonen, Emmanuel Buys, Patrick Sips, Sofie Nimmegeers, Maureen Van den Hemel, Tino Hochepied, Johan Van de Voorde, Peter Brouckaert
Targeting the NO - cGMP pathway: phenotyping of NO-insensitive sGCbeta1 H105F knockin mice
- Harukuni Tokuda, Junko Takayasu, Akira Iida
Ultraviolet B light initiating activity of two-stage mouse skin carcinogenesis and its regulation of cGMP
- Nadejda Valtcheva, Pascal Weinmeister, Franz Hofmann, Susanne Feil, Robert Feil
Analysis of cGKI inhibition by Rp-cGMP analogs
- Yingrui Wang-Rosenke, Stephanie Krämer, Tanja Loof, Sebastian Martini, Dmytro Khadzhynov, Eva Binder, Hans-Hellmut Neumayer, Harm Peters
Activation of the nitric oxide-cGMP signaling pathway precedes resolution in acute anti-thy1 glomerulonephritis
- Pascal Weinmeister, Robert Lukowski, Cornelia Traidl-Hoffmann, Stefan Linder, Franz Hofmann, Robert Feil
Activation of the cGMP/cGKI signalling pathway in primary murine VSMCs accelerates growth
- Matthias E Werner, Andrea L Meredith, Richard W Aldrich, Mark T Nelson
Hyper-contractility and impaired cGMP signaling in the BKCa channel deletion model oferectile dysfunction
- Frank Wunder, Guido Buehler, Jörg Hüser, Stefan Mundt, Martin Bechem, Bernd Kalthof
A luminescence-based assay for sensitive nitric oxide detection
- Angelina Zanesco, Camila de Moraes, AP Dave , LV Rosson, Gilberto de Nucc, Edson Antunes
Exercise training effects on vascular reactivity and metabolic parameters of high caloric-fed Wistar rats
- Tong Zhang, Shunhui Zhuang, Darren E Casteel, Renate B Pilz
A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
- Zongmin Zhou, Anastasia Kotanidou, Charis Roussos, Andreas Papapetropoulos
Activation of soluble guanylyl cyclase (sGC) by the NO/heme-independent activator HMR1766 in cells
|
Print Version
|
|
|
