cGMP: Generators, Effectors and
Therapeutic Implications
Pre-final program
Friday, June 14, 2019
| 13:00-13:55 | Registration & Welcome Reception | |
| 13:55 | Harald Schmidt, Maastrich |
Welcome to Mainz |
| S1 | Session 1: Clinical Translation |
Chairs: Peter Brouckaert, Gent Johannes-Peter Stasch, Wuppertal |
|
| S1-01 14:00 | Mark T. Gladwin, Pittsburgh |
NO-sGC signaling and therapeutics in sickle cell and hemolytic diseases |
| S1-02 14:20 | Christopher Winrow, Boston |
Evaluating soluble guanylate cyclase stimulation for serious central nervous system diseases |
| S1-03 14:40 | Melanie Hemmrich, Wuppertal |
Efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis: Results from the RISE-SSc study, a randomized, double-blind, placebo-controlled phase IIb study |
| S2 | Session 2: Non-canonical signaling and PKG |
Chairs: Jens Schlossmann, Regensburg Franz Hofmann, München |
|
| S2-01 15:00 | David Baker, London |
Targeting the Plasmodium falciparum cyclic GMP-dependent protein kinase to combat malaria |
| S2-02 15:20 | Friedrich W. Herberg, Kassel |
A unique activation mechanism for Plasmodium falciparum PKG |
| S2-03 15:40 | Dominique Soldati-Favre, Geneva |
“Prison Break”: Toxoplasma gondii egress from infected cells is a programmed event governed by a lipid mediator via a guanylate cyclase receptor platform |
| 16:00–16:30 | COFFEE BREAK | |
| S2-04 16:30 | Friederike Cuello, Hamburg |
Redox-regulation of protein kinase G in the cardiovascular system |
| S2-05 16:50 | Thomas M. Moon, Tucson |
Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase |
| S2-06 17:05 | Choel Kim, Houston |
Crystal structure of PKG Iß holoenzyme reveals a trans-inhibiting dimer assembly |
| ML | Murad Lecture | Chair: Ferid Murad, Washington DC |
|
| ML-01 17:20 | Ferid Murad, Washington DC |
Introduction |
| ML-02 17:25-18:15 | David. A. Kass, Baltimore |
GC/PDE crosstalk in the heart |
| 18:15-21:30 | SNACKS, WINE AND BEER | |
| Poster Session 1 | ||
Saturday, June 15, 2019
| S3 | Session 3: The natriuretic peptide pathway |
Chairs: Finn Olav Levy, Oslo Michaela Kuhn, Würzburg |
|
| S3-01 08:30 | Jerid Robinson, Minneapolis |
Guanylyl cyclase-A activation decreases heart size and adiposity in male mice |
| S3-02 08:45 | Michaela Kuhn, Würzburg |
Paracrine cyclic GMP-mediated anti-inflammatory actions of C-type natriuretic peptide |
| S3-03 09:05 | Viacheslav O. Nikolaev, Hamburg |
cGMP microdomains regulate natriuretic receptor signalling in cardiac myocytes |
| S3-04 09:25 | David Paterson, Oxford |
NP/NO regulation of cardiac sympathetic drive |
| S3-05 09:45 | Robert M. Blanton, Boston |
Sacubitril/valsartan improves LV function in chronic pressure overload independently of intact cGMP-dependent protein kinase I alpha signaling. |
| 10:00-10:30 | COFFEE BREAK | |
| S4 | Session 4: Potential new applications |
Chairs: Philip Eaton, London Peter Sandner, Wuppertal |
|
| S4-01 10:30 | Lukas Rüttiger, Tübingen |
A role of the guanylyl cyclase GC-A in auditory function |
| S4-02 10:45 | James R. Klinger, Providence |
Role of natriuretic peptide receptors in pulmonary vascular endothelial function |
| S4-03 11:00 | Philipp Henning, Kassel |
Mutation in cGMP-dependent protein kinase isoform Iα is associated with aortic root dilation and aneurism formation in patients, potentially due to altered kinase activity and cGMP binding kinetics |
| S4-04 11:15 | Justin Percival, Miami |
Soluble guanylate cyclase stimulation ameliorates skeletal and cardiac muscle dysfunction in an mdx model of Duchenne muscular dystrophy |
| 11:30-13:30 | SNACK AND REFRESHMENTS | |
| Poster Session 2 | ||
| 13:30-15:45 | MAINZ VISIT Guided city walk through historic Mainz |
|
| 15:45-17:30 | CULTURAL PROGRAM Organ concert at St Stephan´s church |
|
| 17:30-17:45 | COFFEE BREAK | |
| S5 | Session 5: cGMP network pharmacology |
Chairs: Doris Koesling, Bochum Robert Feil, Tübingen |
|
| S5-01 17:45 | Susan Taylor, San Diego |
Designing an allosteric switch: Lessons learned from PKA |
| S5-02 18:05 | Michael Preedy, London |
Phosphodiesterase 2 promotes nitric oxide/guanylyl cyclase/cGMP signalling in heart failure |
| S5-03 18:25 | Lise R. Moltzau, Oslo |
PDE3 inhibition drives a CNP/cGMP pathway to enhance cAMP signalling in HF |
| S5-04 18:45 | Alexander Pfeifer, Bonn |
Rac1 – sGC/cGMP crosstalk in adipocytes and vascular smooth muscle |
| EL | Evening Lecture | Chair: Harald Schmidt, Maastricht |
|
| EL-01 19:05-19:55 |
Jan Baumbach, München | What I learned from Arnold Schwarzenegger about breast cancer and gene panels |
| 20:00-22:00 | BARBECUE DINNER | |
Sunday, June 16, 2019
| S6 | Session 6: NO-GC structure, modulators and function I |
Chairs: Miriam Cortese-Krott, Düsseldorf Andreas Friebe, Würzburg |
|
| S6-01 08:30 | CANCELLED! Session-Start: 08:50 |
|
| S6-02 08:50 | Wiliam Montfort, Tucson |
How stimulator compounds and nitric oxide bind and stimulate soluble guanylyl cyclase (GC1) |
| S6-03 09:10 | Michael Marletta, Berkeley |
Structural aspects of sGC activation |
| S6-04 09:30 | Doris Koesling, Bochum |
News within NO/cGMP signalling |
| S6-05 09:50 | Florian Sohler, Wuppertal |
Dissection of particulate and soluble guanylyl cyclase pathways based on human genetics |
| 10:05-10:35 | COFFEE BREAK | |
| S7 | Session 7: NO-GC structure, modulators and function II |
Chairs: Robert Lukowski, Tübingen Emmanuel Buys, Boston |
|
| S7-01 10:35 | Juli Jones, Boston |
Praliciguat, a clinical-stage sGC stimulator, improved insulin sensitivity, lipid tolerance and energy utilization in a diet-induced obesity mouse model |
| S7-02 10:55 | Miriam Cortese-Krott, Düsseldorf |
The NO-cGMP pathway in red blood cells |
| S7-03 11:15 | Nikolaus Plesnila, München |
Inhaled nitric oxide as a therapeutic strategy for neurological disorders |
| S7-04 11:35 | Fumito Ichinose, Boston |
Role of plasma NO consumption and sGC signalling in cardiac arrest and CPR |
| S7-05 11:55 | Dieter Groneberg, Würzburg |
Function of pericytes during organ fibrosis |
| S7-06 12:10 | Kjetil Andresen, Oslo |
New FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons |
| 12:25-14:30 | SNACK AND REFRESHMENTS | |
| Poster Session 3 | ||
| S8 | Session 8: Phosphodiesterases |
Chairs: Viacheslav O. Nikolaev, Hamburg Achim Schmidtko, Frankfurt |
|
| S8-01 14:30 | Gary A. Piazza, Mobile |
Novel PDE10 inhibitors with anticancer activity that suppress Wnt-induced β-catenin transcription by activating cGMP/PKG signaling |
| S8-02 14:50 | Frank S. Menniti, Groton |
Phosphodiesterase 9A regulates nitric-oxide-independent cGMP signaling in brain |
| S8-03 15:10 | Chen Yan, Rochester |
PDE10A-cGMP signaling and pathological vascular remodeling |
| 15:30-16:00 | COFFEE BREAK | |
| S9 | Session 9: Poster Presentations |
Chairs: Werner Müller-Esterl, Frankfurt Annie Beuve, Newark |
|
| 16:00-17:00 | 6 selected posters | 5 minute rapid fire oral presentations of selected posters |
| 17:00–18:00 | ORAL & POSTER PRIZE COMMITTEE MEETINGS | |
| 19:00–23:00 | AWARD DINNER & CEREMONY | |