cGMP: Generators, Effectors and
Therapeutic Implications
Final Program (last updated: June 10, 2022)
Friday, June 17, 2022
| 13:00-13:55 | Registration & Welcome Reception | |
| 13:55 | Harald Schmidt, Maastricht |
Welcome to Augsburg |
| S1 | Session 1: Pre-Clinical Translation & Back-Translation |
Chairs: Doris Koesling, Bochum Franz Hofmann, Munich |
|
| S1-01 14:00 | Chris Winrow, Cambridge |
Applying translational approaches for the nonclinical and clinical evaluation of the sGC stimulator CY6463 in CNS diseases |
| S1-02 14:20 | Jos Prickaerts, Maastricht |
sGC modulators as cognitive enhancers: neuronal and/or vascular? |
| S1-03 14:40 | Peter Sandner, Wuppertal |
Discovery and preclinical profiling of the oral sGC activator runcaciguat (BAY 1101042): A novel and effective treatment approach for chronic kidney disease? |
| S1-04 15:00 | Cristian Nogales Calvo, Maastricht |
From phenotype to endotype: Preclinical validation of ROS-cGMPopathies in the Estonian Biobank |
| 15:15-15:35 | COFFEE BREAK | |
| S2 | Session 2: Brain & Neurosensory System |
Chairs: Marlies Knipper, Tübingen Achim Schmidtko, Frankfurt |
|
| S2-01 15:35 | Doris Koesling, Bochum |
Role of NO-GC1 and NO-GC2 in hippocampal cGMP responses induced by glutamatergic agonists |
| S2-02 15:55 | Maya Shelly, Stony Brook |
A localized scaffold for cGMP increaseis required for apical dendrite development in embryonic principal neurons |
| S2-03 16:15 | Jian Yang, New York |
Structural basis of CNG channel function and channelopathy |
| S2-04 16:35 | Morgan Hess, Tübingen |
Stress affects central compensation of neural responses to cochlear synaptopathy in a cGMP-dependent way |
| 16:50–17:00 | Group PICTURE | |
| 17:00–18:30 | POSTER SESSION I | |
| 18:30–19:45 | SNACK AND REFESHMENTS | |
| EL | Evening Lecture | Chair: Harald Schmidt, Maastricht |
|
| EL-01 19:45-20:30 |
Christoph Maack, Würzburg |
Metabolic and redox dysregulation in heart failure |
| 20:30–22:00 | POSTER SESSION II | |
Saturday, June 18, 2022
| S3 | Session 3: Clinical Translation / Cardiovascular |
Chairs: Peter Sandner, Wuppertal Harald Schmidt, Maastricht |
|
| S3-01 08:30 | Thomas Lüscher, London |
Lumpers and splitters: The legacy and future of heart failure management |
| S3-02 08:50 | Paul Armstrong, Edmonton |
Travels with Vericiguat: Insights from a Clinical Scientist |
| S3-03 09:10 | Torsten Kessler, Munich |
Genetic variation affecting cGMP signaling in atherosclerosis and myocardial infarction |
| S3-04 09:30 | Dawood Darbar, Chicago |
Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model |
| S3-05 09:50 | Andreas Busch, Cambridge |
Elderly, postmenopausal females with heart failure with preserved ejection fraction (HFpEF) are responsive to soluble guanylate cyclase (sGC) stimulation: A post hoc analysis of the CAPACITY trial. |
| 10:10-10:30 | COFFEE BREAK | |
| S4 | Session 4: Cardiovascular Diseases and cGMP |
Chairs: Robert Lukowski, Tübingen Lise Román Moltzau, Oslo |
|
| S4-01 10:30 | Friederike Cuello, Hamburg |
Nitroxyl induces blood pressure lowering in part by oxidation of cGMP-dependent protein kinase I |
| S4-02 10:50 | Robert Blanton, Boston |
cGMP-dependent protein kinase I alpha substrates in the regulation of left ventricular function |
| S4-03 11:10 | David A. Kass, Baltimore |
PDE9 inhibition for the treatment of obesity and cardiometabolic syndrome |
| S4-04 11:30 | Viacheslav O. Nikolaev, Hamburg |
Illuminating local cGMP signaling for better cardioprotection |
| S4-05 11:50 | Dulasi Arunthavarajah, Oslo |
Long term delivery of CNP in a mouse model of heart failure with preserved ejection fraction |
| 12:10–13:15 | SNACK AND REFESHMENTS | |
| POSTER SESSION III | ||
| 13:15-17:00 | NETWORKING / SCIENTIFIC EXCHANGE / DISCUSSION OF FRONTIER RESEARCH | |
| 17:00-17:20 | COFFEE BREAK | |
| S5 | Session 5: Other Indications & Non-canonical Signaling |
Chairs: Miriam Cortese-Krott, Düsseldorf Friederike Cuello, Hamburg |
|
| S5-01 17:20 | Sheila Collins, Nashville |
New aspects of NP/cGMP signaling in adipocytes and energy expenditure |
| S5-02 17:40 | Stylianos Michalakis, Munich |
Retinopathy caused by dysfunction of cGMP effectors |
| S5-03 18:00 | Renate Pilz, San Diego |
Protein Kinase G2 Is Required for Androgen Receptor Signaling in Bone |
| S5-04 18:20 | Benjamin Morehouse, Boston |
Cyclic CMP and cyclic UMP in bacterial immunity |
| S5-05 18:40 | Peter van Haastert, Groningen |
Understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis in Dictyostelium |
| 19:00–20:00 | SNACK AND REFESHMENTS | |
| AL | Anniversary Lecture | Chair: Hans-Peter Stasch, Munich |
|
| AL-01 20:00-20:45 |
Harald Schmidt, Maastricht |
Eureka moments in science: From cGMP to systems medicine and back |
| 20:45-22:00 | POSTER SESSION IV | |
Sunday, June 19, 2022
| S6 | Session 6: NO-GC Structure, Modulators, Function |
Chairs: Peter Brouckaert, Ghent Andreas Friebe, Würzburg |
|
| S6-01 08:30 | Dennis J. Stuehr, Cleveland |
sGC maturation to function: Its mechanism, regulation, dynamics, and biological relevance |
| S6-02 08:50 | Sönke Behrends, Braunschweig |
A potential role of GUCY1A2 the human gene encoding the α2-subunit of nitric oxide sensitive guanylyl cyclase in cancer |
| S6-03 09:10 | Juan M. Redondo, Madrid |
NO–GC–PRKG signaling in Marfan syndrome |
| S6-04 09:30 | Annie Beuve, Newark |
Soluble guanylyl cyclase, in addition to cGMP production, mediates NO signaling by using thioredoxin as a nitrosothiol relay under oxidative stress |
| 09:50-10:10 | COFFEE BREAK | |
| S7 | Session 7: Emerging Fields |
Chairs: Sheila Collins, Nashville Jens Schlossmann, Regensburg |
|
| S7-01 10:10 | Daniel Rowland, Bonn |
Compartmentation of cGMP in Adipocytes |
| S7-02 10:25 | Aleksandra Dugandžić, Zagreb |
Uroguanylin activation of brown adipose tissue is age, gender, and phase of the estrous cycle dependent |
| S7-03 10:40 | Rebecca H. Ritchie, Melbourne |
Therapeutic Implications of Nitroxyl (HNO) Donors as a Means of Enhancing cGMP-Mediated Cardioprotection in the Insulin-Resistant Diabetic Myocardium |
| S7-04 10:55 | Lennart Kreutz, Boston / Würzburg |
Origin of NO-GC-positive activated fibroblasts and the role of NO-GC in angiotensin II-induced heart failure |
| S7-05 11:10 | Melanie Cruz Santos, Tübingen |
Angiotensin II-induced cardiac fibrosis is attenuated by myofibroblast-specific cGKI |
| S7-06 11:25 | Gaia Calamera, Oslo | Natriuretic peptides increase cGMP around cardiomyocyte mitochondria and protect against apoptosis |
| 11:40-13:30 | SNACK AND REFESHMENTS | |
| POSTER SESSION V | ||
| S8 | Session 8: Natriuretic Peptides and Receptors |
Chairs: Renate Pilz, San Diego Michaela Kuhn, Würzburg |
|
| S8-01 13:30 | Jens P. Goetze, Copenhagen |
Quantification of natriuretic peptides beyond post-translational modification |
| S8-02 13:50 | Swati Dabral, Würzburg |
C-type natriuretic peptide - cGMP signalling attenuates hyperproliferation of lung pericytes from patients with Pulmonary Hypertension |
| S8-03 14:10 | Lincoln Potter, Minneapolis |
Phosphoryl-regulation of receptor guanylyl cyclases: from chemical discovery to physiologic signalling |
| S8-04 14:30 | Cristina Perez-Ternero, London |
C-type natriuretic peptide regulates metabolic homeostasis |
| 14:50-15:10 | COFFEE BREAK | |
| S9 | Session 9: Technological Advances & New Applications |
Chairs: Robert Lukowski, Tübingen Peter Sandner, Wuppertal |
|
| S9-01 15:10 | Michael Russwurm, Bochum |
NO-induced cGMP generated in cardiac fibroblasts increases cardiac cAMP and phospholamban phosphorylation via inhibition of PDE3 |
| S9-02 15:30 | Xavier Nicol, Paris |
Controlling cGMP downstream signaling with cellular and subcellular specificity using SponGee |
| S9-03 15:50 | Eva-Maria Becker-Pelster, Wuppertal |
The sGC Activator inhale Mosliciguat (BAY 1237592): A new chapter in Pulmonary Hypertension Therapy via Activation of Apo-sGC |
| S10 | Session 10: Poster Presentations “Rapid Fire” |
Chairs: Robert Blanton, Boston Dennis J. Stuehr, Cleveland |
|
| 16:10-16:40 | 5 minute rapid fire oral presentations of selected posters (3-5 selected posters) | |
| 16:40-17:30 | ORAL & POSTER PRIZE COMMITTEE MEETING | |
| 19:00-23:00 | AWARD DINNER & CEREMONY | |