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Program
Print Version
Friday, June 24, 2011
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Opening Ceremony
14:00 |
Reinhard Neubert,
Halle
Gunnar Berg,
Halle
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Welcome to Halle (Saale)
Greetings from the Leopoldina
Nationale Akademie der Wissenschaften
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Session 1
Therapeutic Breakthroughs |
Chair: Mihai Gheorghiade, Chicago
Johannes-Peter Stasch, Wuppertal |
| 14:15 |
Kazuwa Nakao,
Kyoto |
Translational Science of the CNP/GC-B/cGMP System |
| 14:40
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John Burnett,
Rochester |
Modulating cGMP in heart failure by novel natriuretic peptides: clinical results |
15:05 |
Jürgen Behr,
Bochum |
New clinical results with sGC stimulators |
15:30 |
Martin Lefkowitz,
East Hanover |
LCZ696, an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure and hypertension |
Session 2
cGMP in Cardio-Vascular Disease |
Chair: Kazuwa Nakao, Kyoto
John Burnett, Rochester
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| 15:55 |
Alan Maisel,
Chicago |
Biomarkers in kidney and heart disease |
| 16:20 |
John D Parker,
Toronto |
Sustained' use of GTN and ischemic preconditioning |
| 16:45 |
Christopher Newton-Cheh, Boston |
Human genetics, natriuretic peptides and hypertension |
| 17:10 |
Marco Guazzi,
Milan |
Benefits of chronic PDEV inhibition in patients with diastolic heart failure |
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| 17:35–17:55 |
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COFFEE BREAK |
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Session 3
cGMP and Lung |
Chair: James Klinger, Providence
Andreas Papapetropoulos, Patras |
| 17:55 |
Marc Gladwin,
Pittsburgh |
Hemolysis-mediated endothelial dysfunction: role of NO and sGC activators |
| 18:20 |
Michael Wolin,
New York |
Redox regulation of responses to hypoxia and NO-cGMP signalling in pulmonary vascular pathophysiology |
| 18:55 |
Oleg Evgenov,
Boston |
Nitric oxide-independent stimulation of soluble guanylate cyclase attenuates pulmonary fibrosis |
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19:20–20:15
Session 4
Guided Poster Session |
SNACK & REFESHMENTS, WINE & BEER |
| Molecular Mechanisms |
Chair: Soenke Behrends, Braunschweig
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| Heart/Lung |
Chair: Oleg Evgenov, Boston
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| Clinics/Biomarkers |
Chair: Guido Boerrigter, Rochester
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| Evening Lecture |
Chair: Harald Schmidt, Maastricht
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| 20:15–21:15 |
Paul Vanhoutte,
Hong Kong |
Endothelial dysfunction and vascular disease. |
Saturday, June 25, 2011
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Session 5
sGC Structure and Function |
Chair: Michael Marletta, Berkeley
Franz Hofmann, München |
| 08:30 |
Michael Marletta,
Berkeley |
A molecular view of the regulation of sGC activity |
| 08:55 |
Focco van den Akker,
Cleveland |
Structural insights into sGC activation by different sGC activators |
| 09:15 |
Susan Taylor,
San Diego |
PKA: assembly of dynamic macromolecular signalling |
| 09:40 |
Wolfgang Dostmann,
Burlington |
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication |
| 10:05 |
Choel Kim,
Houston |
The crystal structures of PKG Iß (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding |
| 10:30–11:00 |
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COFFEE BREAK |
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Session 6
cGKI and Cardio-Vascular System |
Chair: Michael Mendelsohn, New Yersey
Doris Kösling, Bochum |
| 11:00 |
Peter Brouckaert,
Gent |
Apo sGC mice: NO-independent role for sGC and sGC independent role for NO |
| 11:25 |
Thomas Krieg,
Cambridge |
Characterization of mice with a deletion of cGKI in cardiomyocytes and the effect on cardioprotection through either postconditioning or mitochondria-targeted S-nitrosothiol |
| 11:50
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Alessandro Cataliotti,
Rochester |
Long-term cardiac pro-BNP gene delivery prevents the development of hypertensive heart disease in SHR |
| 12:15
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Jens Schlossmann,
Regensburg |
Vascular and renal function of cGMP signalling |
| 12:40 |
Eiki Takimoto,
Baltimore |
cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2 |
| 13:05 |
Enrico Patrucco,
München |
cGMP kinase I, cardiac hypertrophy and PDE inhibition |
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13:30–14:30
Session 7
Guided Poster Session |
SNACKS AND REFRESHMENTS AT THE POSTERS |
Cardiorenal/
Urology |
Chair: Peter Sandner, Wuppertal
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| Platelets/VSMC |
Chair: Andreas Papapetropoulos, Patras
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| Other Functions of cGMP |
Chair: Alexander Pfeifer, Bonn
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| 15:00–16:00 |
ORGAN RECITAL
Irénée Peyrot in the Marktkirche, Halle |
| 16:00–18:00 |
Halle VISIT
Guided walking tour through the historic Halle |
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| 18:00–20:00 |
SNACKS AND REFRESHMENTS AT THE POSTERS |
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Ferid Murad Lecture |
Chair: Ferid Murad, Washington |
| 20:00–21:00 |
Michael Mendelsohn, New Jersey |
Halle-luja: Eine Kleine Nachtmusik about cGMP signalling in blood vessels |
Sunday, June 26, 2011 |
Session 8
Other Functions of cGMP |
Chair:
Ikuo Tooyama, Otsu
Romain Lefebvre, Ghent |
| 08:30 |
Joseph Beavo,
Seattle |
Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse? |
| 08:55 |
Doris Koesling,
Missouri |
NO signalling in synaptic transmission |
| 09:15 |
Philip Eaton,
London |
High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIɑ knock-in mouse |
| 09:40 |
Takaaki Akaike,
Kumamoto |
Cellular signalling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide |
| 10:05 |
Renate Pilz,
La Jolla |
Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex |
10:30–11:00 |
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COFFEE BREAK |
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Session 9
cGMP and Ion Channels |
Chair: Gilberto De Nucci, Sao Paulo
Jens Schlossmann, Regensburg |
| 11:00 |
Jörg Wegener,
München |
cGMP/cGKI signalling in peripheral VSM does not involve TrpC3 or TrpC6 channels |
| 11:25 |
Gilberto De Nucci,
Sao Paulo |
Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of rattlesnake corpus cavernosum |
| 11:50 |
Andreas Papapetropoulos,
Patras |
Regulation of vascular growth and tone by hydrogen sulfide |
| 12:15 |
Michaela Kuhn,
Würzburg |
A novel pathway of cGMP |
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12:40–14:00
Session 10
Guided Poster Session |
SNACKS AND REFRESHMENTS AT THE POSTERS |
| NO/sGC/PKG |
Chair: Harald Schmidt, Maastricht
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| Natriuretic Peptides |
Chair: Michaela Kuhn, Würzburg
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| Other cGMP Topics |
Chair: Roland Seifert, Hannover
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Session 11
cGMP and Anti-Proliferation |
Chair: Ferid Murad, Washington
Vicente Felipo, Valencia |
| 14:00 |
Vicente Felipo,
Valencia |
cGMP modulates stem cells differentiation to neurons in brain in vivo: pathological implications |
| 14:25 |
Ikuo Tooyama,
Otsu |
BNP signalling is crucial for embryonic stem cell proliferation |
| 14:50 |
Ronald Fiscus,
Henderson |
Protein kinase G type-I phosphorylates c-Src at serine-17 and promotes cell survival, proliferation and attachment in human mesothelioma and non-small cell lung cancer cells |
| 15:15–15:45 |
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COFFEE BREAK |
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Session 12
Upcoming
Topics |
Chair: Günter Schultz, Berlin
Robert Lukowski, Tübingen |
| 15:45 |
William Durante,
Missouri |
Vasoprotection by heme oxygenase-1: interactions with sGC |
| 16:10 |
Annie Beuve,
Newark |
NO resistance in Angiotensin II-induced hypertension is associated with S-nitrosation of soluble guanylyl cyclase |
| 16:50 |
Roland Seifert, Hannover |
Cyclic CMP and cyclic UMP: new (old) second messengers |
| 17:15 |
Alexander Pfeifer,
Bonn |
Role of cGMP/PKG in fat tissue |
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Session 13
Poster Prize
Session |
Chair: Adrian Hobbs, London
Annie Beuve, Newark |
| 17:40–18:00 |
N.N. |
Each candidate may talk for 3 min and show up to 3 slides or overheads and allow for 2 min question time |
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| Session 14 Committee Meetings |
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| 18:00–18:20 |
Poster Prize Committee |
Selected out of poster presentations |
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Young Investigator Award |
Selected out of all oral presentations |
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19:00
20:00
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GUIDED TOUR THROUGH ART COLLECTION MORITZBURG
COCKTAIL AND DINNER AT MORITZBURG
AWARD CEREMONY
FAREWELL PARTY |
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Poster Session
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Molecular Mechanisms
- Dieter Müller, Hanna Höfeld, Fritz Buck, Ralf Middendorff
A novel natriuretic peptide-degrading protease in human lung
- Christian Krawutschke, Doris Koesling, Michael Russwurm
cGMP signals in smooth muscle cells and cardiac myocytes
- Lise Román Moltzau, Jan Magnus Aronsen, Silja Meier, Cam Nguyen, Geir Christensen, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Eirik Qvigstad
The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle
- Dieter Müller, Mirjam Hildebrand, Jörn Lübberstedt, Ralf Middendorff
Tissue- and development-specific glycosylation states of the natriuretic peptide receptors guanylyl cyclase-A (GC-A) and GC-B
- Brent W Osborne, Andrew T Menke, Donald K Blumenthal, Wolfgang R Dostmann
A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Ia
- Filipa Mota Quinteiro, Paul Gane, Anne-Sophie Rebstock, Roberta Worthington, Michela Simone, Snezana Djordevic, Adrian Hobbs, David Selwood
Design and development of novel non-peptide agonists at NPR-C
- Nadiia Rozmaritsa, Torsten Christ, Erich Wettwer, Ursula Ravens
NO-donors induce cross talk between cGMP and cAMP in signalling to human atrial L-type Ca2+ current
- Irina G Rybalkina, Masami Shimizu-Albergine, Sergei D Rybalkin
Calcium/Calpain mediated regulation of cyclic nucleotide phosphodiesterases, PDE3A and PDE5, in human platelets
- Raphaela Schwappacher, Thuan Diep, Gerry Boss, Renate Pilz
cGMP and PKGI are required for vascular BMP signaling
Heart/Lung
- Eva Maria Becker, Johannes-Peter Stasch, Martin Bechem, Hubert Truebel
Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on "desaturation"
- Justin S Bice, Gary F Baxter
Targeting of soluble guanylyl cyclase limits infarct size in a model of acute myocardial infarction
- Robert M Blanton, Eiki Takimoto, Angela Lane, Mark J Aronovitz, Richard H Karas, David A Kass, Michael E Mendelsohn
Protein kinase G I alpha activates an anti-remodeling signaling pathway in the heart via an interaction with the MAPKKK mixed lineage kinase 3
- Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Johannes-Peter Stasch, John C Burnett, Jr
Activation of heme-free soluble guanylate cyclase with cinaciguat has beneficial cardiorenal actions when added to furosemide in experimental heart failure
- Peter König, Dieter Groneberg, Roland Jäger, Andreas Friebe
NO-sensitive guanylyl cyclase is expressed in pericytes but absent from endothelial cells in the murine lung
- Baktybek Kojonazarov, Michaela Lang, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani
Effects of riociguat in severe experimental pulmonary hypertension
- Nils Kronas, Birte Peters, Alwin E Goetz, Jens C Kubitz
Inhaled and intravenous application of a stimulator of the soluble guanylate cyclise (BAY 41-8543) reduces pulmonary vascular resistance in a model of septic shock
- Michaela Lang, Baktybek Kojonazarov, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Schermuly
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
- Silja Meier, Jan Magnus Aronsen, Ivar Sjaastad, Finn Olav Levy, Tor Skomedal, Jan-Bjørn Osnes, Eirik Qvigstad
Cyclic GMP generated by natriuretic peptide receptor B enhances ß1-adrenoceptor signaling in normal and failing hearts
Clinics/Biomarkers
- Guido Boerrigter, Lisa C Costello-Boerrigter, Gail J Harty, John C Burnett, Jr.
Bioavailability of intravenous versus subcutaneous administration of the dual GC-A and GC-B designer natriuretic peptide cenderitide in healthy canines
- Reiner Frey, Wolfgang Mück, Sigrun Unger, Michael Reber, Jörn Krätzschmar, Corina Becker, Georg Wensing
No pharmacodynamic (PD) and pharmacokinetic (PK) interaction of riociguat (BAY 63-2521) and aspirin
- Reiner Frey, Wolfgang Mueck, Michael Becka, Joern Kraetzschmar, Georg Wensing
Antiplatelet effects of aspirin are not affected by the soluble guanylate cyclase activator cinaciguat (BAY 58-2667)
- Julia Grupe, Andrea Neumann, Johannes-Peter Stasch, Kirsten Leineweber
Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance
- Jeson S Sangaralingham, Denise M Heublein, Joseph P Grande, Alessandro Cataliotti, Andrew D Rule, Paul M McKie, Fernando L Martin, John C Burnett Jr
C-Type Natriuretic Peptide: a potential urinary biomarker for renal remodeling and fibrosis during aging
- Christian Scheerans, Martin Blunck, Wolfgang Mueck, Reiner Frey
Pharmacokinetic analysis of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in individuals with renal impairment compared to healthy controls
- Markus Schwefer, Aleksandra Mandecka, Helen Schmicker-Helf, Andreas Brückmann, Thomas Lehmann, Ingeburg Schauer, Frank Kramer, Marcus Blum, Harald Lapp
Dynamic Vessel Analyzer (DVA) – a new method to detect endothelial dysfunction in chronic heart failure: correlation between DVA and asymmetric dimethyl arginine (ADMA)
- Yuichi Tamura, Tomohiko Ono, Takashi Kawakami, Masaharu Kataok, Motoaki Sano, Toru Satoh, Keiichi Fukuda
Arterial methemoglobin level predicts therapeutic effectiveness of the PDE5 inhibitors in patients with in idiopathic pulmonary arterial hypertension
Cardiorenal/Urology
- Markus Alter, Ina Ott, Karoline von Websky, Oleg Tsuprykov, Yuliya Sharkovska, Katharina Krause-Relle, Jens Raila, Andrea Henze, Axel Kretschmer, Johannes-Peter Stasch, Berthold Hocher
Additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone
- Caroline Feuerstacke, Sabine Tasch, Johanna Volkmann, Dieter Müller, Ralf Middendorff
PDE expression and contractility of seminiferous tubules of the human testis
- Sandra Geschka, Axel Kretschmer, Yuliya Sharkovska, Oleg V Evgenov, Andreas Hucke, Bettina Lawrenz, Berthold Hocher, Johannes-Peter Stasch
Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats
- Ilia Goltsman, Elena Ovcharenko, Aaron Hoffman, Giora Feuerstein, Zaid Abassi, Joseph Winaver
Rosiglitazone improves the natriuretic response to atrial natriuretic peptide in rats with experimental congestive heart failure: possible involvement of a post-guanylate cyclase mechanism
- Dieter Groneberg, Peter König, Andreas Friebe
Fertility in male mice lacking NO-sensitive guanylyl cyclase
- Andrea Mietens, Caroline Feuerstacke, Sabine Tasch, Gerrit Eichner, Ralph Theo Schermuly, Friedrich Grimminger, Dieter Müller, Ralf Middendorff
Acute effects of phosphodiesterase 5 (PDE5) inhibition, ANP and NO on epididymal contractility are preserved despite chronic PDE5 exposure
- Dieter Müller, Michail S Davidoff, Ralf Middendorff
Distinct ageing- and androgen-dependent effects on cGMP signalling proteins in three male rat urogenital organs (bladder, prostate, epididymis)
- Alexandra Oudot, Delphine Behr-Roussel, Sarah Poirier, Jacques Bernabé, Peter Sandner, François Giuliano
Experimental evidence that a combination of sGC stimulator BAY 60-4552 and PDE5 inhibitor vardenafil could salvage ED-patients with insufficient response to PDE5 inhibitors after cavernous nerve injury
- Elisabeth Schinner, Armin Kurtz, Franz Hofmann, Jens Schlossmann
Suppression of kidney fibrosis by cGMP-dependent protein kinase I
Platelets/VSMC
- Emmanuel S Buys, Michael J Raher, Andrew Kirby, Sarah R Hayton, Laurel T Tainsh, Patrick Y Sips, Peter Brouckaert, Mark J Daly, Kenneth D Bloch
Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase ?1 deficient mice
- Stepan Gambaryan, Elke Butt, Joerg Geiger, Suzanne M Lohmann, Ulrich Walter
Specific PKG inhibitors: do they really exist?
- Steven A Fisher, Ylva Mende, Brunhilde Wirth, Kang Fu
Transformer (Tra2ß): master regulator of myosin phosphatase alternative splicing and smooth muscle responses to NO/cGMP signaling
- Claudia Heine, Nico Scherf, Katja Sygnecka, Ute Egerland, Thorsten Hage, Heike Franke
Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model
- Ronald Jäger, Dieter Groneberg, Andreas Friebe
Role of NO/cGMP signalling in VEGF-mediated angiogenesis
- Katharina Salb, Elisabeth Schinner, Jens Schlossmann
Function of IRAG and the phosphorylation of the InsP3R-I for the NO/cGMP-dependent inhibition of platelet aggregation
- Kathrin Schulte, Doris Koesling, Evanthia Mergia
Does a reduction of vascular relaxation promote hypertension?
- Samantha Yuen, Ozgur Ogut, Frank V Brozovich
Differential phosphorylation of LZ+/LZ- MYPT1 isoforms by PKGI?: implication for vascular reactivity
Other Functions of cGMP
- Emmanuel S Buys, Yu-Chieh Ko, Sarah Hayton, Alexander Jones, Laurel Tainsh, Ruiyi Ren, Andrea Giani, Emma Abernathy, Haiyan Gong, Douglas J Rhee, Peter Brouckaert, Meredith Gregory, Louis R Pasquale, Kenneth D Bloch, Bruce Ksander
sGCa1-deficient mice: a novel murine model of spontaneous primary open angle glaucoma
- Sarah Cosyns, Johannes-Peter Stasch, Peter Brouckaert, Romain A Lefebvre
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice
- Katja Jennissen, Bodo Haas, Wolfram S Kunz, Alexander Pfeifer
cGMP and cAMP differentially regulate differentiation and function of brown adipocytes
- Christina Kruuse, Saurabh Gupta, Elisabeth Nilsson, Lars Kruse, Lars Edvinsson
Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries – relevant to migraine?
- Caitlin J McFarland, Christian K Nickl, Brent W Osborne, Indra Neil Sarkar, Wolfgang R Dostmann
cGMP-dependent protein kinase from Toxoplasma gondii: functional expression in E. coli and molecular characterization
- Michaela M Mitschke, Daniela Scholz, Katrin Zimmermann, Peter Mayer, Bodo Haas, Alexander Pfeifer, Ana Kilic
Protein kinase G is a key regulator of murine white adipogenesis
- Isabel Schönle, Angela Neitz, Thomas Mittmann, Doris Koesling, Evanthia Mergia
PDE2, a component of the NO/cGMP signalling in the hippocampus
- Beate Spiessberger, Dieter Saur, Ursula Seidler, Anurag K Singh, Robert Lukowski, Franz Hofmann
The role of cGMP-cGKI-signaling for duodenal bicarbonate secretion
- Amparo Urios, ML Garcia-Torres, Carla Gimenez-Garzó, Cristina Aguado, Juan A del Olmo, Carmen Marin, Miguel Civera, Fernández N Cassinello, José Ortega, Antonio Ferrandez, J. Martinez-Valls, Miguel A Serra, José M Rodrigo, Vicente Felipo, Carmina Montoliu
Metabilism of cyclic GMP in nonalcoholic fatty liver disease in morbid obesity
NO/sGC/PKG
- Sönke Behrends, Mareike Busker, Nadine Haase, Tobias Haase, Jan Krähling, Monika Linnenbaum
Conjoined NO-sensitive guanylyl cyclases
- Kerstin Yvonne Beste, Johannes-Peter Stasch, Volkhard Kaever, Roland Seifert
Evidence for two catalytic centers and Mn2+ as physiological cofactor of soluble guanylyl cyclase
- Swati Chauhan, Iraida Sharina, Emil Martin
G-protein regulator LGN inhibits the activity of soluble guanylyl cyclase
- Kelly Decaluwé, Bart Pauwels, Sara Verpoest, Robrecht Thoonen, Emmanuel Buys, Peter Brouckaert, Johan Van de Voorde
Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation
- Dorota Gryko, Emil Martin
New vitamin B12 derivatives activates sGC
- Wiebke Janssen, Yves Schymura, Astrid Wietelmann, Johannes-Peter Stasch, Himal Luitel, Norbert Weissmann, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Thomas Braun, Werner Seeger, Ralph Theo Schermuly
Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice
- Michael Sobolevsky, Swati Chauhan, Iraida Sharina, Emil Martin
Gemfibrozil as a potential heme-independent sGC activator
- Robrecht Thoonen, Haihua Zhang, Yuichi Abe, Heather Nickerson, Mark Aronovitz, Pierre Chambon, Richard H Karas, Michael E Mendelsohn
Smooth muscle cell specific deletion of the PKGIa target RGS2 induces vascular dysfunction and hypertension
- Byung-Kuk Yoo, Isabelle Lamarre, Jean-Louis Martin, Fabrice Rappaport, Michel Negrerie
Dynamics of NO interacting with soluble guanylate cyclase from 1 ps to 0.1 s and induced structural transitions
Natriuretic Peptides
- Syed Ameenuddin, Elise A Oehler, John C Burnett Jr, Horng H Chen
Treatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model
- Reshma S Baliga, Sarah L Trinder Christopher J Scotton, Rachel C Chambers, Raymond J MacAllister, Adrian J Hobbs
Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis
- Wen Chen, Birgit Gaßner, Sebastian Börner, Michaela Kuhn
Atrial natriuretic peptide increases the albumin permeability of mouse skeletal muscle microcirculation by the caveolae-mediated transcellular pathway
- Lisa C Costello-Boerrigter, Guido Boerrigter, Sarah Mangiafico, Alessandro Cataliotti, John C Burnett Jr
The novel dual GC-A and GC-B designer natriuretic peptide, cenderitide (CD-NP), enhances the renal actions of furosemide in a model of severe heart failure
- Lisa C Costello-Boerrigter, John A Schirger, Wayne L Miller, Guido Boerrigter, Horng H Chen, Ruth Kempf, Candace Y Lee, John C Burnett Jr
Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure
- Marina Dobrivojevic, Aleksandra Sindic, Bojana Nikitovic, Bayram Edemir, Eberhard Schlatter, Wolf-Georg Forssmann, Jochen R Hirsch
Interaction between bradykinin and urodilatin - a possible mechanism of clinical relevance
- Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi, Russell Araki, Jennifer Villarreal, Glenmar Obedencio, Anne Kanta, Erik Sandvick, Craig Hill, Kevin Dement, Uwe Klein, Donavon McConn, William Martin, Sharath S Hegde
Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension
- Fernando L Martin, Paul M McKie, S Jeson Sangaralingham, Tomoko Ichiki, Gerald E Harders, Horng H Chen, John C Burnett Jr
Cenderitide, a novel dual GC-A and GC-B receptor activator, is a potent chronic cardiorenal fibroinhibiting peptide which suppresses aldosterone and reduces proteinuria in models of cardiorenal fibrosis
- Ronald Jäger, Corina Russwurm, Doris Koesling, Michael Russwurm
Activation of PDE10 and PDE11
Other cGMP Topics
- Nirmalya Basu, Sayanti Saha, Sandhya S Visweswariah
Signaling via guanylyl cyclase C: cGMP, Src and p21
- Heike Burhenne, Kim Tappe, Kerstin Beste, Ulrike Voigt, Corinna Spangler, Dimitrios Tsikas, Volkhard Kaever, Roland Seifert
Quantitation of cyclic nucleotides in mammalian cells and in human urine by high-performance liquid chromatography/mass spectrometry
- Corina Russwurm, Ronald Jäger, Doris Koesling, Michael Russwurm
Comparative analysis of PDE10A isoforms
- Barbara Lies, Dieter Groneberg, Dieter Saur, Peter König, Andreas Friebe
Nitrergic relaxation of gastrointestinal smooth muscle: role of interstitial cells of Cajal and smooth muscle cells
- Robert S Stephens, Laura E Servinsky, David B Pearse
cGMP-mediated antioxidant signaling: a role for the c-Abl tyrosine kinase
- Ulrike Voigt, Heike Burhenne, Lena Sonnow, Christine Wölfel, Corinna Spangler, Daniel Ladant, Dara W Frank, Volkhard Kaever, Roland Seifert
The effector protein ExoY secreted by Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for GTP
- Katharina Werner, Frank Schwede, Hans-Gottfried Genieser, Jörg Geiger, Elke Butt
Quantification of cAMP and cGMP analogs in intact cells: pitfals in enzyme immunoassays for cyclic nucleotides concentration in pulmonary artery from rats submitted to lung ischemia/reperfuion
- Sabine Wolter, Marina Golombek, Andreas Hammerschmidt, Frank Schwede, Hans-Gottfried Genieser, Roland Seifert
Activation of cGMP-dependent protein kinase Ia and cAMP-dependent protein kinase A isoforms by cyclic nucleotides
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